T2/T2*: Applications
Hyeong-Geol Shin1
1Seoul National University, Korea, Republic of
Synopsis
This educational presentation introduces how the microscopic tissue organization influences transverse relaxation properties (e.g., T2 and T2*) and how we inversely estimate the microstructural information from the MR signals. The relaxation mechanisms related to the microstructure and the mathematical model describing the effects are discussed.
Syllabus
The transverse relaxation properties of MRI (e.g., T2 and T2*) have facilitated the differentiation of brain anatomy by weighting the relaxation. With the recent advances in postprocessing and physical modelling, the changes in relaxometries are investigated in a quantitative manner as in T2(*) mapping. Because the relaxation parameters are correlated with cellular-level environment of tissue, the quantitative approaches offer a useful tool to understand and monitor the brain pathology. In addition, the transverse relaxation map is influenced by magnetic susceptibility sources in a voxel and, therefore, delineate the susceptibility distribution. Furthermore, the brain tissue has highly organized microstructures, especially in the white matter. The effects of this molecular and microscopic organizations may not be fully explained by a simple relaxation model but by water compartmentalization and susceptibility anisotropy. This complicated signal behavior (e.g., multi-exponential decay in T2(*) relaxation) pave the way to assess the microstructure information like myelin contents.Acknowledgements
No acknowledgement found.References
No reference found.
Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)