Paramagnetic Agents I
Eric M. Gale1
1Radiology, Massachusetts General Hospital/ Harvard Medical School, Charlestown, MA, United States
Synopsis
MRI using targeted molecular probes enables non-invasive diagnosis, quantification, and longitudinal monitoring of the cell- and molecular-level determinants driving disease. However, developing a molecular MR imaging probe is challenging. MR imaging probes are detected with low sensitivity and overcoming this limitation is paramount amongst the challenges to probe development. This talk describes the molecular mechanisms underpinning paramagnetic relaxation enhancement and how these parameters may be tweaked for imaging probe optimization. The talk is designed for an audience that understand T1 and T2 relaxation and how these properties relate to image contrast.
Synopsis
MRI using targeted molecular probes enables non-invasive diagnosis, quantification, and longitudinal monitoring of the cell- and molecular-level determinants driving disease. However, developing a molecular MR imaging probe is challenging. MR imaging probes are detected with low sensitivity and overcoming this limitation is paramount amongst the challenges to probe development. This talk describes the molecular mechanisms underpinning paramagnetic relaxation enhancement and how these parameters may be tweaked for imaging probe optimization. The talk is designed for an audience that understand T1 and T2 relaxation and how these properties relate to image contrast.Acknowledgements
No acknowledgement found.References
No reference found.
Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)