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Correlation analysis between quantitative parameters of mDIXON-Quant sequence and liver function in patients with liver cirrhosis1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Philips Healthcare, Beijing, China, 3the First Affiliated Hospital of Dalian Medical University, Dalian, China
Synopsis
Evaluation of liver reserve function is crucial for patients with cirrhosis and is helpful for the determination of the surgical plan formulation, the evaluation of treatment process and prognosis, and the operation of cirrhosis. However, there is still lacking a clinically useable non-invasive technique to measure the abnormality of liver function. The purpose of this study is to investigate the potential correlation between Fat Fraction (FF), R2* and liver function indexes in patients with cirrhosis using mDIXON-Quant sequence. We found that there was a moderate correlation between R2* value and liver function assay indexes in liver cirrhosis.
Introduction
Liver function evaluation plays an important role in the treatment of liver cirrhosis and the evaluation of liver function failure after treatment[1]. However, there is still lacking a clinically useable non-invasive technique to measure the abnormality of liver function. The mDIXON-quant technique enables reliable separation of water and fat signals, and measurement of fat fraction and R2*[2]. In this study, we investigated the potential correlation between FF, R2* and liver function indexes in patients with cirrhosis using mDIXON-Quant and evaluate the clinical values of mDIXON-Quant for evaluating the abnormality of liver function.Methods
This study has been approved by the institutional IRB. We had retrospectively analyzed 23 patients with liver cirrhosis from October 2019 to October 2021. mDIXON-Quant was acquired on a 3.0 T MRI Scanner (Ingenia CX, Philips Healthcare, the Netherlands). The diagnosis was confirmed by clinical symptoms, laboratory tests, and MRI examination. The detailed MR scanning parameters were shown in Table 1. The data of liver function test (total bilirubin, total bile acid, prealbumin, albumin, γ-glutamyl transpeptidase (GGT), asparagine, Alanine aminotransferase, alkaline phosphatase, and prothrombin time) were recorded. The excluded criteria in this study were: A, clinical laboratory information was not complete or the date of assay inspection sampling more than 5 days of MRI examination; B, liver surgery patients; C. Intrahepatic space-occupying lesions. After finishing MR examination, the raw data were uploaded to the Philips workstation. FF and R2* value were measured by two observers (MRI diagnostic experience for 3 years and 2 years) respectively. (Region of Interests) ROIs were placed manually in the left hepatic lobe, liver right anterior, and posterior lobe of liver maximum level. The statistical analysis was performed with SPSS 22.0 (IBM). The inter-class correlation coefficient (ICC) was used to test the consistency of measurements. Spearman analysis was used to explore the relationship between FF, R2* and hepatic function tests indexes in patients with liver cirrhosis.Results
Table2 showed that the statistical analysis revealed a negative correlation between R2* and GGT as well as Alkaline phosphatase (r = 0.495 and 0.599, P＜0.05). There is no correlation between other parameters(P＞0.05).Discussion and Conclusion
In this study, the correlations between R2* of liver cirrhosis and the liver function indexes are observed in patients with cirrhosis. Since the clinical liver function indexes could reflect the degree of abnormality of liver function, mDIXON-Quant sequence might be a potential clinical method to evaluate liver function non-invasively.Acknowledgements
NoReferences
1. Huh J, Ham SJ, Cho YC, et al. Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials. BMC Med Imaging. 2019 Nov 15;19(1):89.
2. Zhang Y, Wang C, Duanmu Y, et al. Comparison of CT and magnetic resonance mDIXON-Quant sequence in the diagnosis of mild hepatic steatosis[J]. Br J Radiol. 2018, 91(1091): 20170587.
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