Daehun Kang1, Myung-Ho In1, Maria A Halverson1, Nolan K Meyer1, Erin M Gray1, Thomas K Foo2, Radhika Madhavan2, Zaki Ahmed1, Hang Joon Jo3, Brice Fernandez4, David F Black1, Kirk M Welker1, Joshua D Trzasko1, John Huston, III1, Matt A Bernstein1, and Yunhong Shu1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2GE Global Research, Niskayuna, NY, United States, 3Department of Physiology, Hanyang University, Seoul, Korea, Republic of, 4GE Healthcare, Buc, France
Synopsis
For multi-echo EPI, the
T2*-weighted echo combination (T2EC) is a commonly used pre-processing
step to boost the data quality. We assessed the benefit of T2EC in
high-spatial-resolution multi-echo fMRI with explained variances and functional
connectivity detectability. The performance was evaluated and compared with single-echo
EPI for resting state fMRI on a compact 3T scanner with high-performance gradients.
It was shown that a large portion of unwanted signal variance was globally suppressed
through T2EC. Multi-echo acquisition shows improved image intensity and enhanced
functional sensitivity in brain regions affected by signal-dropout.
Introduction
Multi-echo(ME)-fMRI is
known to provide better BOLD contrast sensitivity due to higher signal-to-noise
ratio and broadened optimal T2* coverage than single-echo (SE) fMRI acquisition1. ME-fMRI is especially suitable for the compact 3T (C3T)
scanner equipped with high slew rate gradient (peak slew-rate 700T/m/s) 2 as the reduced echo-spacing can compensate for the extra
time needed for additional echoes. Whole-brain high-spatial-resolution resting-state
ME-fMRI was shown to be feasible on the C3T scanner with practical echo times
for all three echoes2. T2*-weighted echo combination (T2EC) was
used as a preprocessing step for ME echo-planar-imaging (ME-EPI) acquisition to
yield improved temporal SNR. In our study, to analyze the benefit of T2EC, we assessed
the marginal explained variance of T2EC and compared with the variance
associated with other artifact regressors3. Also, we investigated the
improved resting-state functional connectivity (FC) detection, especially in
regions suffering from signal dropout when compared with a SE-fMRI acquisition.Methods
Under an IRB-approved
protocol and with written informed consent, T1-weighted anatomical images
(1 mm3 isotropic), multi-band (MB) ME-EPI (TR = 0.93s, TEs = 11.8, 29.8,
47.8ms, FA = 59°, in-plane×MB accelerations = 2×4, voxel size 2.43mm3, 52 slices, full k-space sampling, total scan time = 5mins × 2 sessions)
and SE-EPI images (TR = 0.7s, TE = 30ms, FA = 52°, total scan time = 11mins, otherwise
same as ME-EPI) were acquired from 17 healthy volunteers with a 32-channel head
coil (Nova Medical, Wilmington, MA,US).
The preprocessing pipeline
for artifact-reduction was depicted in Fig. 1, using AFNI, SUMA, and FreeSurfer
software packages1,3-8. For FC
estimation, the artifact-reduced time series were bandpass-filtered with a
frequency range of 0.009 to 0.1 Hz and smoothed by a Gaussian kernel with a 4
mm FWHM. To focus on the sole benefit of T2EC, all other processing steps are
kept the same between all comparisons.
The marginal explained variance R2 value
is applied to represent the proportion of signal variance reduction for a
certain preprocessing step to the variance with all preprocessing steps3. R2
is defined as: $$$R^2_{step}≡1-SS_{total}/SS_{step}$$$, where SStotal is the
error sum of squares with all preprocessing steps and SSstep is the
error sum of squares with all preprocessing steps except for a certain step.
Without the bandpass filtering and spatial smoothing on datasets, R2
are evaluated for the conventional artifact-related regressors of RETROICOR
(Physio)6, ANATICOR (WMe)3, motion
and ventricles (CSFe), and for T2EC in ME datasets, separately in GM
and WM voxels across all subjects.
To investigate the effect of T2EC on BOLD detection,
the cortical coverage ratio was evaluated on the 3D
surface model for both SE and ME datasets9. Also, the
effect of the BOLD sensitivity improvement on FC
was also investigated by ROI-based FC. With 168 cortical parcellations defined
by FreeSurfer software, the inter-ROI FCs were calculated as Pearson
correlation coefficient between ROIs. Fisher-transformed FCs composed a FC
matrix of 168×168. Paired Student’s t-test for group comparison was applied to the FC matrices obtained from SE- and ME-EPI datasets.
We thresholded inter-ROI FCs with a statistically significant difference
(p<0.01) and a selected FC value (Fisher(r) > 0.3) and counted the number
of the inter-ROI FCs survived by the two thresholds.Results
In
Fig. 2(a,b), the conventional regressors for multi-echo acquisitions showed a
similar trend in R2 as those for single-echo acquisitions. R2
for T2EC were substantially higher than the other regressors, which indicated that
a fairly large portion of signal variances was removed through T2EC. In Fig. 2(d),
R2 for T2EC in general accounts for most of the explained variance.
Fig.
3 showed the cortical coverage ratio, in which the T2EC enhanced signal
intensity even in some high-susceptibility regions. Particularly, cortex along
the medial orbital sulci (olfactory sulci) and anterior transverse collateral
sulci showed signal intensity improvement across almost all of subjects10.
ROI-based group FCs were given in Fig. 4(a), where the
upper and lower triangles are for SE and ME datasets, respectively. Difference
of ROI-based group FCs was given in Fig. 4(b), where upper and lower triangles denote
group difference without/with the thresholds, respectively. Most of significant
group differences with thresholds showed higher FC magnitude for ME than SE. As
indicated in Fig. 4(c), the four regions (indicated with arrows) which had statistically
and functionally significant differences than others were consistent with the regions
indicated in Fig. 3.
Fig. 5 showed all inter-ROI group FCs derived from
the four regions marked in Figs 3 and 4. SE datasets produced only limited
number of weak inter-ROI FCs while ME datasets detected more and stronger inter-ROI
FCs.Discussion
Explained variance of echo-combining compared
with the various of other regressors on ME-fMRI dataset shows strong thermal noise
suppression result from T2EC, which leads to high temporal SNR for ME
acquisition. Inter-ROI FC analysis comparison between SE-fMRI and ME-fMRI shows
the improved robustness in BOLD sensitivity of ME-fMRI especially in the
inferior frontal and temporal lobes, important brain regions that commonly suffer
from signal dropout on BOLD imaging studies.Conclusion
For a high-spatial-resolution
resting-state fMRI study performed on a C3T, T2*-weighted
echo combination preprocessing for ME-fMRI reduced thermal-noise-related signal
variance and improved BOLD sensitivity in signal-dropout brain regions.Acknowledgements
This work
was supported by NIH U01 EB024450 and NIH U01 EB026979.References
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