Chris Moore1, Joe Stickley1, Abigael Clough2, Claire Nelder2, Robert Chuter1, Ananya Choudhury3, Damien McHugh1, and Michael Dubec1,4
1CMPE, The Christie NHS Foundation Trust, Manchester, United Kingdom, 2Radiotherapy Services, The Christie NHS Foundation Trust, Manchester, United Kingdom, 3Research and Development, The Christie NHS Foundation Trust, Manchester, United Kingdom, 4University of Manchester, Manchester, United Kingdom
Synopsis
MR-Linacs enable daily functional
imaging to be performed in patients being treated with radiotherapy. In this
work, the diffusion sequence developed by the MRL Consortium biomarkers working
group underwent technical validation, showing accurate and repeatable phantom
ADC measurements. Daily, whole-prostate ADC mapping was also performed in
patients undergoing treatment for prostate cancer on an MRL. No significant
differences were observed in whole-prostate ADC during the course of treatment for conventional and stereotactic ablative body radiotherapy (SABR)
treatments. Absence of significant change in ADC could be related to the fact
that patients were treated with neo-adjuvant hormone therapy prior to
radiotherapy.
Introduction
The MR-Linac (MRL) is the next
step in image guided radiotherapy, allowing daily anatomical and functional
imaging [1].
Prostate apparent diffusion coefficient (ADC) has been shown to act as a
biomarker for radiotherapy treatment effectiveness when measured at treatment
follow-up [2],
but it is not regularly measured during treatment. If prostate ADC can be
measured during treatment then it may be possible to predict the effectiveness
of treatment and potentially adapt plans or boost intra-prostatic lesions based
on functional information [3].
At our institution, MR-Linac
prostate treatments are delivered either with 60 Gy in 20 fractions (conventional
treatment) or as 36.25 Gy in 5 fractions (SABR treatment). This work set out to
compare ADC changes between conventional and SABR treatments.Methods
The Elekta MRL Biomarkers working
group diffusion-weighted imaging (DWI) sequence (single shot EPI, b = 0, 150,
500 s/mm2, TE/TR = 65/2931 ms, voxel size = 1.9 mm x 1.9 mm x 4 mm) [4] was tested for
accuracy and repeatability over 6 monthly QA sessions using the quantitative
imaging biomarkers alliance (QIBA) diffusion phantom [5].
The sequence was run on five
patients undergoing conventional treatment and four patients undergoing SABR
treatment recruited under the MOMENTUM study [6].
The purpose of the DWI imaging was explained to patients who then provided
written consent to undergo imaging for research purposes following their daily
treatment. At each treatment, patients had the opportunity to opt out of this
additional imaging: after acquiring clinical T2-weighted images and delivering
treatment, verbal agreement was sought from patients before proceeding with the
DWI scan.
Treatment contours defined on the
pre-treatment T2 weighted anatomical planning scans were rigidly registered to
the daily T2 weighted images and the ROIs were deformed across in the Monaco
treatment planning system [7].
These were then rigidly registered and copied across to the daily DWI weighted b = 0
images.
ADC maps were generated from b =
150, 500 s/mm2 images, and median values were extracted from whole
prostate regions of interest (ROIs), obtained by eroding the registered
treatment contours by 2 voxels to ensure surrounding tissue was not included in
the ROI (fig. 1).
ADC maps were generated from b =
150, 500 s/mm2 images, and median values were extracted from whole
prostate regions of interest (ROIs), obtained by eroding the registered
treatment contours by 2 voxels to ensure surrounding tissue was not included in
the ROI (fig. 1).
A 2-sided, paired t-test was used
to determine if there were any significant changes in ADC between the start and
end of treatment for either conventional and SABR treatments with significance
defined as p < 0.05 to reject the null hypothesis.Results
ADC measurements using b = 150
and 500 s/mm2 images were found to be highly accurate (mean %
difference < 2.7%) and repeatable (coefficient of variation < 2.0 %, Fig.
3) in the expected clinical range of ADC (ADC > 0.6 x10-3 mm2/s),
accuracy and repeatability are poorer at lower ADC.
There was no significant change between the start and end of
treatment for either the conventional treatment (p = 0.81) or the SABR
treatment (p = 0.14).
Furthermore, images were suboptimal and it was head to
distinguish tumours from healthy prostate tissue in the DWI images and ADC maps.Discussion
There were no significant changes
in whole prostate ADC between the start and end of treatment. This study was
limited by the low numbers of patients and the fact that patients underwent
neo-adjuvant hormone therapy in addition to their radiotherapy treatment. This
neo-adjuvant therapy has been shown to reduce the changes in prostate ADC caused
by radiotherapy [8].
Additionally, we were only able to assess the whole prostate, rather than
having an individual region of interest for the tumour; this is due to the fact
that in the current workflow, the dose is prescribed to the whole prostate.
This study did however show that
daily DWI measurements on the MRL are feasible and produce accurate and
repeatable results in phantoms.
Further optimisation of image resolution and
contrast is needed to help distinguish tumour from prostate tissue.
Further work is planned to
improve the imaging sequence and collect data from a greater number of
patients.Conclusion
Daily DWI imaging is feasible on
the MRL using the Elekta biomarkers working group DWI sequence, which produces
accurate and repeatable ADC measurements in phantoms.
There was no significant
difference in prostate ADC between the start of treatment and immediately after
the end of treatment for either conventional or SABR treatments. Acknowledgements
No acknowledgement found.References
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