Michael Vaeggemose1,2, Rolf F. Schulte3, Christoffer Laustsen2, Esben Søvsø Szocska Hansen2, and Nikolaj Bøgh2
1GE Healtcare, Broendby, Denmark, 2MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark, 3GE Healtcare, Munich, Germany
Synopsis
Deuterium metabolic imaging (DMI) has emerged
as a novel biomarker comparable to 18FDG PET by adding quantitative
metabolic kinetic capabilities at high field (>3T). The main barrier for
widespread clinical adoption, is the availability of high field clinical scanners.
The aim of this study is to determine if DMI for neurological applications is
feasible on a clinical 3T MRI scanner. Our findings suggests that it is indeed feasible,
and that metabolic breakdown product (Glutamine/Glutamate) can be quantified around
120 min after ingestion.
Introduction
Deuterium metabolic imaging has emerged as a
novel biomarker mimicking 18FDG PET by adding
quantitative metabolic kinetic capabilities [1], [2]. The MR method has received renewed
interest as imaging was demonstrated in humans at B0 = 4T, a field strength close
to conventional clinical MRI scanners [3]. Nevertheless, the challenges of adapting
the method (signal-to-noise and spectral separation) to clinical scanners may
be the main barrier for widespread adoption. If translation would be possible
applications could go beyond 18FDG PET applications to include quantitative
analysis of glycolytic pathways [4], determination of glutamate/glutamine
(Glx), and lactate conversion in diseases such as brain cancer [2]. Consequently, the aim of this study
is to determine if deuterium imaging of a healthy human brain is feasible on a clinical
3T MRI scanner.Methods
The
brain of a healthy fasted volunteer was scanned in a 3T (GE 750 MR scanner) at baseline,
15 min, 30 min, 40 min 120 min and 180 min after oral glucose ingestion. Following an initial baseline scan the subject
was given 60 g [6,6-2H]-glucose (DLM-349-CTM, Cambridge Isotope Laboratories) dissolved into
50 ml tap
water (0.75 g/kg), a dose similar in concentration as
described in literature [3]. A commercial dual tuned 1H /2H
head coil (PulseTeq) was used for proton and deuterium imaging. Deuterium imaging was performed using a 3D
density weighted CSI (matrix 12x12x12, field-of-view = 250 mm, isotropic resolution
= 20.8 mm3, repetition time (TR) = 170 ms, flip angle = 70o,
bandwidth = 5000 Hz, excitations
= 3066, points
= 796, acquisition time = 8:41 min) as anatomical reference a fast-spin-echo T2-weigthed
proton MRI was applied. Deuterium images were post-processed with spectral
integration at D2O chemical shift (4.7 ppm) at a range of 0.76 ppm (50Hz) and
filtered with a 3D Gaussian kernel to reduce noise. Results
Deuterium
imaging of the brain after oral glucose ingestion showed an increase in deuterium
water signal (D2O) after 30 min, peaking at 120 min and with a slight drop
after 180 min (Figure 1).
Analysis of
the total signal spectra, from the images, acquired at baseline and 180 min
after glucose ingestion point to an increase in Glx (Figure 2, green dotted line).
Assessment of deuterium spectra in two select
voxels, in slice 8, at baseline and 180 min after glucose ingestion indicate low
signal-to-noise ratio. Nevertheless, as seen in the spectra of the total signal
(Figure 2) an increase in Glx is observed at 180 min (Figure 3, B.3).Conclusions
Deuterium metabolic imaging (DMI) of a healthy
human brain with oral glucose ingestion is feasible on a clinical 3T MRI
scanner. DMI images was recorded in 8:41 min, supporting methods feasibility in
a clinical application. Findings suggests an optimal time for imaging of 120 min
after ingestion followed by a steady state in the following hour. Interestingly,
results suggests that Glx can be measured in the brain at 3T. Acknowledgements
No acknowledgement found.References
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