Gawon Lee1, Ji Wan Son1, Ken SaKaie2, Woojin Jung3, and Se-hong Oh1,2
1Division of Biomedical engineering, Hankuk University of Foreign Studies, Yongin-si, Gyeonggi-do, Korea, Republic of, 2Imaging institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 3AIRS Medical, Seoul, Korea, Republic of
Synopsis
Even
subtle differences in masks can generate systematic but avoidable errors in QSM
calculations. We believe these errors propagate through the calculation of the
background phase. In this work, we assessed the effect of the mask on the QSM,
selected optimal mask generation method and Deep Learning-based efficient mask generation method for in-vivo has been presented. This
study represents the first step towards a fully-automated and optimal workflow
for QSM calculation.
Introduction
Several studies have shown that quantitative
susceptibility mapping (QSM) is a candidate biomarker for neurological
disorders such as Parkinson’s Disease, Multiple Sclerosis and Alzheimer’s
Disease 1-3.
QSM is reconstructed from the phase of
gradient echo images(GRE). This reconstruction is notoriously ill-posed4.
The basic steps in QSM reconstruction are phase unwrapping, background phase
removal, and calculation of magnetic susceptibility.
Removal of the background phase is particularly
problematic and depends sensitively on separating the background from tissue
with a brain tissue mask. However, mask generation methods have not been standardized
for QSM. Systematic study of the effects of mask generation methods on QSM
reconstruction has not, to our knowledge, been performed.Researchers use
various methods for mask generation, such as FSL BET5, STI Suite6
and manual tracing. Because each mask generation method utilizes a different
algorithm and inclusion/exclusion criteria, the masks differ. As a result,
there is variation in the QSM results that depend solely on the choice of mask.
Such variability can interfere with valid interpretation in a clinical setting.
Therefore, a method for optimal mask generation method is needed for accurate
QSM.
In this work, 1) the effect of mask on the
QSM is assessed, 2) based on it, optimal mask generation method is selected and
3) Deep Learning (DL) based efficient mask
generation method for in-vivo has been proposed. The
QSM with optimized mask reveal substantially improved image quality,
demonstrating potential for clinical use.Methods
Digital
phantom
To investigate the
effects of the tissue mask in QSM reconstruction and determine optimal mask
generation, we performed digital phantom experiments using the Zubal MRI head
phantom7. Magnetic susceptibility values were mapped to the phantom
following the values reported by Karsa et al.8. Phase data was
generated by convolution with the dipole kernel.
We compared four
different mask generation methods: manual tracing, FSL BET, FSL BET with pixel
dilation and STI Suite.
Manual
tracing masks were defined from 3-dimensional images by two trained raters
following guidelines by Tamraz et al.9 and Lim et al.10 .
The threshold value of FSL BET was set empirically to
the value of 0.5. Pixel dilation was performed by a disk-shaped kernel with a one-voxel
radius.
The
local field map of phantom data was generated by the V-sharp method11,
and QSM is reconstructed by iLSQR12. To find the best mask
generation method, error rates between ground truth and recalculated QSM from
masks in cortex, white matter, thalamus, and globus pallidus were compared.
Deep Learning
An overview of the deep learning approach is in Figure 1. The OASIS
dataset13, consisting of 150 subjects, was used for training data
and validation data. Label dataset was generated as the most optimal method
investigated in the phantom experiment.
This network was trained with patch-based learning with a patch size
of 128x128x64 and 3D U-net architecture. Dice-loss and Adam-w are utilized for
updating network parameters. Data augmentation is also applied with Scale
Intensity, Random Flip, Randp, Crop, Random Affine transform, Adding Gibbs
noise, and Gaussian Smoothing.
The trained network is evaluated with hemorrhagic
patient data scanned on 3T (Philips, IRB approved). The patient data were
acquired with 0.43x0.43x2mm3 voxels. Images were resampled to the
isotropic 1x1x1mm3 voxels by applying crop and padding. For in-vivo,
the QSMnet+ 14 was used for QSM map reconstruction.
Results
Phantom
study
Figure 2 shows the result from the digital phantom.
Figure 2A shows error maps. Error is highest in regions such as the Sylvian
fissure (green arrow). The STI Suite mask eroded noticeably more tissue than
the other methods, leading to a high error. Figure 2B shows mean errors in each
ROI. The manual tracing mask shows the lowest error, overall.
Deep
Learning Approach
In the phantom
experiment, we found that the manual tracing method was optimal. Therefore, we
trained the network with a manual segmentation dataset. Figure 3 shows the
difference map between validation results of trained network and manual
training masks and the comparison graph of number of voxels for each mask.
Masks generated by the DL approach match the manually segmented masks closely,
albeit with a smoother edge. The number of voxels in each slice is plotted
together. It shows DL-based mask has similar to manual tracing results and the
differences are negligible
In figure 4 shows
results from the OASIS dataset. As compared with results generated with a
manually segmented mask, susceptibility values associated with the
FSL-generated masks are systematically low in the central vein area (red
arrows), while values associated with the deep learning-generated mask match
closely.
Patient
Data
Figure 5 shows QSM
maps from a hemorrhagic patient. Results using FSL mask with various thresholds
are presented together. Figure 5 shows
different QSM maps varying on mask generation methods. Also, Compared to DL-based method, the FSL BET mask
shows eroded noticeably in the upper brain area.
Conclusions & Disscusions
This study represents the first step
towards a fully-automated and optimal workflow for QSM calculation. Even subtle
differences in masks can generate systematic but avoidable errors in
susceptibility calculations. We believe these errors propagate through the
calculation of the background phase. Future work will entail an end-to-end
calculation of QSM images within the deep learning framework.Acknowledgements
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1A2C4001623)
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