Ashley A Williams1,2, Yongxian Qian3,4, and Constance R Chu1,2
1Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 3Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 4Center for Biomedical Imaging, NYU Langone Health, New York, NY, United States
Synopsis
This work
evaluates mono- and bi-exponential UTE-T2* relaxation in 6 tread mark regions
of knee cartilage of 18 participants with ACL-injury prior to reconstruction
surgery and in 15/18 participants 2 years after surgery. Bi-exponential T2*short
had a smaller fractional contribution than T2*long in all regions
examined. However, T2*short accounted for a higher fraction of total
signal in deep cartilage layers compared to superficial. While both mono- and
bi-exponential UTE-T2* analyses showed significant longitudinal changes, bi-exponential
analyses did not exceed the sensitivity of mono-exponential UTE-T2* for
detection of knee cartilage compositional changes over the first two years
following ACL reconstruction.
Introduction
Bi-exponential
UTE-T2* relaxation of knee cartilage in ACL tear (ACLT) and ACL-reconstructed
(ACLR) cohorts have not been examined. For other short-T2 tissues, such as tendons
and menisci, the short-component of bi-exponential T2* analyses showed greater
sensitivity to intra-substance degenerative changes1-3 than long-components or mono-exponential assessment. The
goal of this work is to evaluate bi-exponential UTE-T2* relaxation mapping of
human knee cartilage early after ACL injury and to examine longitudinal changes
in bi-exponential UTE-T2* components following ACLR. We hypothesize that the
short-component of bi-exponential UTE-T2* relaxation will be more sensitive to
cartilage compositional changes over 2 years following ACLR than
mono-exponential UTE-T2*.Methods
Mono- and bi-exponential UTE-T2* relaxation was measured in the knee
cartilage of 18 participants with ACL-injury prior to reconstruction surgery
and in 15/18 of the participants who returned for follow-up imaging 2 years
after ACLR. All subjects provided informed consent for these IRB-approved studies.
3-D AWSOS (Acquisition-Weighted Stack of Spirals)4 images were acquired using a 3T Siemens
MAGNETOM Trio scanner and an 8-channel knee coil (In vivo Inc.). Eleven images
at TE=0.6-40ms were collected with a 140mm FOV and 256x256 matrix for 547µm
resolution in-plane and 2mm section thickness. Other acquisition parameters
were: 60 slices, 24 in-plane spirals, 11.52ms spiral readout time, 5µs data
sampling interval, and FA/TR 30/80ms. Scan time was 1.92 min per TE-image. TE images were interpolated to a 512x512
matrix prior to T2 relaxation fitting.
Pixel-by-pixel mono- and bi-exponential T2 fits5; 6 were generated with pM2
software (General Labs Cloud, LLC). UTE-T2* relaxation components were assessed
in “tread mark” regions of interest (ROIs) on 6 cartilage surfaces including the
medial and lateral femurs and tibial plateaus, patella and trochlea7; 8 using custom MATLAB
software (TheMathWorks, Inc.), Figure 1. The tread marks were 10mm wide (medial
to lateral) manually segmented from 5 contiguous slices from the center of
their respective compartments. Full-thickness, superficial and deep
cartilage layers were separately assessed in each tread mark region. Identical
cartilage masks were applied to all relaxation parameter maps, Figure 2. UTE-T2*
relaxation component values were averaged across all voxels within a tread
mark, or tread mark layer, for each participant and time-point. Normality was
assessed by Shapiro-Wilk tests.
Longitudinal changes in UTE-T2* relaxation components between the
pre-surgery and 2-year post-ACLR imaging sessions were assessed with two-tailed paired
t-tests (or Wilcoxin signed-rank tests for non-normally distributed data).
Statistical analyses were performed with SPSS (v25, IBM).Results
Bi-exponential
UTE-T2* Cartilage Relaxation Components After ACLT
Twelve of the 18
participants underwent pre-surgical UTE-T2* imaging within 3 months of their
ACL injuries. A description of both
mono-exponential UTE-T2* (T2*mono) relaxation times and
bi-exponential short (T2*short) and long (T2*long)
UTE-T2* relaxation times, as well as the fraction of the total signal from each
bi-exponential component in these 12 participants is reported in Table 1. The fractional contributions of T2*short
and T2*long varied with cartilage region and layer, but T2*short
had a smaller fractional contribution than the T2*long in all
regions examined. However, T2*short accounted for a higher fraction
of total signal in deep cartilage layers compared to superficial. While both
the T2*mono and T2*long relaxation times were higher in
superficial compared to deep cartilage, T2*short was lower in superficial
compared to deep cartilage in all compartments except the patella.
Longitudinal
Changes in Bi-exponential UTE-T2* Cartilage Relaxation Components After ACLR
Two-year follow-up MRI for 14/15
longitudinal subjects were adequate for bi-component analyses. Both mono- and
bi-exponential UTE-T2* analyses showed significant changes over the first 2
years following ACLR, Table 2. T2*mono decreased 12% and 24% in deep
cartilage of the medial femur and tibia (p=0.017,
0.006, respectively). In superficial cartilage, T2*mono decreased 5%
on the patella but increased 7% on the trochlea (p=0.032, 0.042, respectively). Bi-exponential T2*long decreased
24% in deep medial tibial cartilage (p=0.016),
and the fraction of signal due to T2*short decreased 29% in
superficial trochlear cartilage (p=0.003,
with complimentary increased fraction from T2*long). Although,
bi-exponential analysis suggested trends for additional longitudinal changes of
T2*short, T2*long, and their fractional intensities, no
other significant bi-exponential UTE-T2* component changes were observed. No changes
were detected in full-thickness cartilage regions by either mono- or
bi-exponential analyses.Discussion
In
this small cohort, T2*short was not found to be more sensitive than T2*mono
to knee cartilage compositional changes in weight-bearing condylar cartilage over
2 years following ACLR. Notably, decreases to T2*mono detected in
deep medial femoral tread marks were consistent with decreases previously
reported in much smaller, single-slice ROIs of these same participants.9 Of interest, T2*mono in the broader tread
mark analyses detected decreases in deep medial tibial cartilage that were not
previously observed with the smaller ROIs. Bi-exponential analysis suggests that
these decreases are due to greater mobility of the water contributing to T2*long.
Changes to the relative contributions of T2*short and T2*long in
superficial trochlear cartilage and an attendant lengthening of T2*mono
may be indicative of loosening of the superficial matrix in response to altered
loading following ACLR in these regions.7Conclusion
While bi-exponential analyses did not exceed the sensitivity of
mono-exponential UTE-T2* for detection of cartilage compositional changes
following ACLR in this initial study, the data supports further investigation
of regional differences to bi-exponential changes in larger cohorts.Acknowledgements
NIH RO1 AR052784 (PI – CR Chu) and DOD W81XWH-18-1-0590 (PI-CR Chu).References
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