Michelle W. Tong1,2, Aniket A. Tolpadi1,2, Alex Beltran1,2, Sharmila Majumdar2, and Valentina Pedoia 2
1Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California San Francsico, San Francisco, CA, United States
Synopsis
This
study explores the use a deep learning network to generate T1rho maps from T2 maps
for knee MRI. T1rho maps have clinical value in the diagnosis of osteoarthritis
in addition to T2 maps while T2 maps are more widely adopted and available in
clinical datasets. This study found synthetic T1rho maps images maintain
excellent fidelity for data collected in a research setting while performance
is reduced for data collected in a clinical setting. This
work elucidates the promise of deep learning in accelerating imaging protocols
through domain adaptation as opposed to more common reconstruction approaches.
Introduction
Osteoarthritis
(OA) is an irreversible disease characterized in part by degeneration of the
protective cartilage between bones, necessitating early detection. Unlike
conventional MRI sequences, compositional sequences like T1rho and T2
mapping afford sensitivity to early biochemical changes in cartilage, such as extracellular
matrix degradation1 and decreases in proteoglycan content that can
precede morphological changes2. As such, T1rho mapping is one
promising avenue for early OA detection, but it suffers from long acquisition
times and SAR concerns that prevent widespread adoption in the clinic3-5. On the other hand, T2 mapping has been more widely adopted for clinical and
research purposes, and has been acquired in the absence of T1rho mapping in
large studies like the Osteoarthritis Initiative. An algorithm that
predicts T1rho maps from T2 maps would be useful in adding new information to
improve clinical outcomes and open possibilities for further investigations
from large cohort studies that have acquired T2 maps.Methods
Image Acquisition and Segmentation
Magnetization-prepared
angle-modulated partitioned k-space spoiled gradient echo snapshots (MAPSS)
T1rho/T2 mapping echo images were acquired in 844 knees across 573 healthy and
diseased patients6. Scans were done in the
sagittal plane at 3T using GE MR750 scanners and QT8PAR knee coils across three
studies: UCSF study (research setting), UCSF/MAYO/HSS multi-center study
(research setting), or in addition to a clinical protocol (clinical setting). Echo images were acquired
using a spin-lock or fast-spin echo sequence with fat suppression (TSL=0/2/4/8/12/20/40/80
or 0/10/40/80ms; spin-lock= 500Hz; TE=0, 12.9, 25.7, 51.4ms or
2.9/13.6/24.3/45.6ms; TR=1.2s; FOV=14cm; slice thickness=4mm; reconstructed
matrix=256x256; bandwidth readout= ±62.5 kHz; 64-view acquisition). To
calculate T2 or T1rho maps, all echo images relevant to the given preparation
were extracted and registered to the TE/TSL=0ms shared echo using a 3D rigid registration algorithm with
a normalized mutual information criterion7. Levenberg-Marquardt
fitting of registered echos yielded ground truth T1rho and T2 maps8.
Cartilage segmentations were obtained from the
TE=0ms echo using a 3D V-Net architecture for the UCSF and multi-center
studies, and through manual annotation of images from the clinical protocol. Input
slices were split into training, validation, and testing sets such that each subject
was only in one set and each study was similarly represented.
Training
A U-Net encoder-decoder network (Fig. 1) was trained to
predict T1rho
images from T2 map images. A hyperparameter search identified the optimal
loss function, intensity scaling of input images, learning rate, and number of
epochs to minimize the normalized root mean squared error (NRMSE) between the
predicted and ground truth images. Performance was evaluated using the NRMSE,
structural similarity (SSIM), peak signal-to-noise ratio (PSNR), and visual
inspection. Results
Input, ground truth, and predicted maps for two subjects whose
images both were acquired in research settings are shown in Fig. 2. Predicted T1rho maps maintain excellent fidelity to ground truth in
both cases visually and have NRMSEs under 2.5% for both patients. Notably, patterns in
T1rho cartilage were preserved despite ground truth T2 maps exhibiting much
different textures and elevation patterns, particularly in central tibial
cartilage.
Model evaluation metrics are calculated and reported in Fig. 3.
Performance in patients whose images were acquired in research settings was
especially strong, maintaining NRMSEs comfortably under 3%; although
performance decreased in the less controlled clinical acquisitions.
Bland-Altman plots in Fig. 4 emphasize these trends, as plots among
patients in both research settings (UCSF and Multi-Institutional) showed very
tight limits of agreement and minimal bias in predicted T1rho cartilage maps,
while limits were wider despite the line of equality being contained in
clinical settings. For all studies, correlation plots and Pearson’s r revealed strong
correlations between predicted and ground truth T1rho in cartilage (Fig. 5).Discussion and Conclusions
The encoder-decoder pipeline generates T1rho maps that maintain
strong fidelity to ground truth, especially for maps acquired in research
settings. Notably, predicted maps indicate the network generated new
information not present in input T2 maps. In Fig. 2, while there is some
degree of correlation across ground truth T1rho and T2 values, there are
substantial differences between observed T1rho and T2 map patterns in the
central tibial cartilage regions of both patients. Despite these correlations, the network provides
strong reconstructions of this region in both cases.
Past studies have shown that 6.4% changes in T1rho values can be
clinically significant9. For patients whose images were acquired
under research conditions, T1rho predictions were far beneath this threshold. This indicates the pipeline’s promise in generating high quality maps with
acceptable quantification errors. In the more uncontrolled clinical
environment, quantification error rates were 12.4% which is well above this threshold. Further development is needed to make the network robust to poorer
quality control procedures that are likely seen in clinical acquisitions of
this sequence as opposed to research.
This
work elucidates the promise of deep learning in accelerating imaging protocols
through domain adaptation as opposed to more common reconstruction approaches.
With further development, a pipeline like this could extract additional
diagnostic information from already acquired T2 maps. Future work may consider
image texture analysis and alterations to the network and training procedures
to improve the generalizability of the network. Acknowledgements
We would like to acknowledge AF ACL consortium, and our funding sources NIH UH3AR076724 and NIHR01AR078762.
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