Annemarijke Van Luijtelaar1, J.P. Michiel Sedelaar2, Joyce G.R. Bomers1, and Jurgen J. Fütterer1
1Medical Imaging, Radboudumc Nijmegen, Nijmegen, Netherlands, 2Urology, Radboudumc Nijmegen, Nijmegen, Netherlands
Synopsis
Magnetic resonance imaging-guided focal laser ablation is used as alternative
to radical treatment while preserving healthy tissue and subsequently reduce
treatment-related morbidity in patients with localized prostate cancer.
Preliminary results of this prospective, non-randomized, clinical phase 2
study using a remote-controlled manipulator, show promising results in both
oncological and functional outcomes in a group of 20 patients with low- to
intermediate-risk (Gleason Score ≤ 4+3) prostate cancer. Transrectal magnetic
resonance imaging-guided focal laser ablation is a promising outpatient
procedure under local anesthesia for localized prostate cancer. It provides a
fast and minimally-invasive strategy while reducing treatment related
complications and side-effects.
Introduction
Prostate cancer (PCa) is the most frequent malignancy in the male
population and has a substantial socio-economic impact (1). At present, treatment
choice for patients with low- to intermediate risk of disease progression lies
between active surveillance (AS) and radical therapies, i.e. radical
prostatectomy or radiotherapy (2-3). Radical treatment options provide an
excellent long-term cancer efficacy control but also come with treatment-related
complications and side-effects, i.e. urinary incontinence, sexual dysfunction
and bowel urgency (4-5). Minimally-invasive intervention options aim for
targeted PCa therapy while preserving healthy tissue and subsequently reduce
treatment-related morbidity (6-7). Focal laser ablation (FLA) is a thermal
ablation technique using energy provided by an optical laser fiber that is
applied within the cancerous tissue by either a transrectal or transperineal
approach. This results in direct-focused cell death by raising the temperature
of the targeted tissue above 60°C. Image-guided interventions using magnetic
resonance imaging (MRI) provide improved treatment accuracy due to excellent
soft-tissue contrast, multi-planar and anatomical imaging (8). Real-time feedback
of the heat distribution within the prostatic tissue allows accurate focal
treatment nearby adjacent structures. The use of MRI-guided FLA holds the
promise to provide a faster, less expensive and less invasive alternative to
radical PCa treatment (9). Despite recent studies, long-term follow-up is
lacking and the efficacy and functional outcomes are not well established. This
study evaluates the use of transrectal MRI-guided and robot-assisted FLA in
patients with low- to intermediate risk PCa in an outpatient setting under
local anesthesia.Methods
Fifty-three men of ≥45 years with newly diagnosed low- to
intermediate-risk (Gleason score ≤ 4+3 or ISUP≤3) PCa and a prostate specific antigen (PSA) level ≤15 ng/mL,
will undergo transrectal MRI-guided (3.0-T
Skyra; Siemens Healthineers, Erlangen, Germany) FLA in a prospective,
non-randomized, clinical phase 2 study. The treatment is performed as an
outpatient procedure under local anesthesia. A MRI-compatible CE marked remote-controlled
manipulator (RCM) (Soteria Medical, The Netherlands) is used for needle
guidance towards the area of interest (figure 1). When the needle guide was
targeted to the lesion, the laser fiber was introduced and the ablation was
started (Leonardo laser system, Biolitec, Germany). The thermal distribution is
monitored using real-time temperature mapping in two directions (axial/sagittal:
TR 24 ms TE 8 ms, flip angle 15°, resolution 1.0x1.0mm, slice thickness 5.0mm).
Multiple ablations are performed to cover the whole tumor (figure 2). Follow-up
includes of PSA level measurement and dedicated questionnaires for functional outcome
(IPSS and ICIQ for urinary outcomes, EORTC QLQ-PR25 and IIEF for sexual
outcomes, ) after 6 weeks, 3,6,12,and 24 months, multiparametric prostate MR
examination at 6,12 and 24 months and a targeted MR-guided biopsy of the
ablation zone at 12 months after the FLA procedure. Furthermore, re-treatment
percentage, success rate and complication rates were assessed during follow-up visits.Results
Thus far, twenty
patients were successfully treated with MR-guided FLA. The median PSA level at
baseline was 6.8 (2.7-15) ng/mL. Four patients had a Gleason 3+3 and 16 patients
had a Gleason 3+4 prostate tumor. All treated lesions were located in the
peripheral zone. The number of ablations varied from 3 to 6 per procedure. One
patient was unable to urinate directly post-procedure and a transurethral
catheter was inserted for 5 days. A second patient received a transurethral
catheter 2 days after the procedure due to acute urinary retention. Despite the
adequate antibiotic policy, one patient developed a fever and was admitted to
the hospital for intravenous antibiotic administration in the week following
the procedure as a result of an infection. No other complications were
recorded.
Completed two-year follow-up is known for the
first nine patients. The mean (range) PSA level at 6, 12 and 24 months after
treatment were 4.4 (0.56-16.1) ng/mL, 3.8 (0.36-8.1) ng/mL and 3.8 (0.38-9.0) ng/mL
respectively. Two patients had an increased PSA level due to a second (newly
developed) non-significant (Gleason Score 3+3) prostate tumor. Two other patients
underwent a radical prostatectomy after initial treatment with FLA due to
evidence of a newly developed significant (Gleason Score ≥3+4) tumor on MRI and histopathology during
follow-up. The multiparametric prostate MRI and subsequent targeted biopsies of
all other patients showed no evidence of recurrent or residual disease during
follow-up. There were no significant
changes in functional outcome and quality of life.Discussion
This research shows the pre-liminary results of a prospective phase-2
study. The PSA levels decreased severely and the majority of the treated
patients had no presence of significant recurrent or residual tumor on multi-parametric
MRI or in the histopathology results during follow-up. Furthermore, none of the
patients showed significant changes or deterioration of functional outcome
measurements and quality of life. Despite the promising results, this study is
limited by its single-center and longitudinal study design, which may lead to a
selection bias. All included patients were widely counseled for other (definitive)
treatment options or active surveillance.Conclusion
Transrectal robot-assisted MRI-guided FLA provides promising early
results in oncological control and effectiveness without significant changes in
functional outcome and quality of life in patients with low- to
intermediate-risk PCa.Acknowledgements
No acknowledgement found.References
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