Synopsis

When compared to other molecular imaging methods like PET, MRI/MRS-based techniques are less frequently used in clinical practice. This is partly due to the low sensitivity, in particular for MR spectroscopic methods. On the other hand, molecular MR imaging techniques that require contrast agents, depend on often lengthy regulatory procedures for their clinical approval. The application of hyperpolarized agents is still inhibited by its relatively complex procedure for daily use in the clinic. For a broad clinical use of molecular MRI and spectroscopy, it is necessary that the respective MR technique is without alternative to answer a particular clinical question.