Functional MRI and diffusion tensor imaging are increasingly incorporated in clinical practice in order to identify eloquent brain regions. The latter is important in case of brain tumors where pre-operative identification of these regions may affect the surgical procedure and predict post-operative clinical outcome. In this 30min educational session, we will explore the fundamental clinical applications of task and resting-state fMRI and DTI/Tractography in neuro-oncology by processing pre-operative fMRI and DTI data of real brain tumor cases and discussing pre-operative findings with regards to findings from electrical stimulation and patients’ post-operative clinical outcome.