Synopsis

Intra-tumour heterogeneity is present on various levels in ovarian and kidney cancers. Different tumour regions are genetically heterogeneous, show a variable physiology, different metabolic profiles and different morphological appearances. Each of these properties can be investigated in isolation, done typically in the past. Our aim is, however, to understand where Imaging, Transcriptomics, Genomics and Metabolomics provide complementary information and where information is redundant. For this, we require spatially resolved data integration which is key to biological understanding of what we see on imaging as well as for non-invasive evaluation of tumour micro-environment and better prediction of treatment response and outcome.