Synopsis

Diffusion MRI is a non-invasive method to interrogate the micro-structure of tissue in humans and animal models alike. Diffusion Tensor Imaging (DTI) is the most common applied technique in this context and can be used to quantify the amount and the directionality of water diffusion in the tissue. Diffusion contrast is typically achieved by means of pulsed magnetic field gradients. This educational lecture will briefly review the basics of diffusion MRI and focus on discussing the role and benefits of high-performance gradient systems for microstructural investigations of brain and heart in the preclinical setting.