Synopsis

A relevant number of COVID-19 patients may present with neurological symptoms in the acute/subacute phase of the disease. Neuroimaging can reveal a wide spectrum of CNS abnormalities, from ischemic lesions to microhemorrhages as well as meningoencephalitis and extensive white matters lesions. Advanced imaging techniques (DWI, DTI, f-MRI) may reveal underlining “inflammation of the brain” in case of persistent neurological symptoms and an unremarkable MRI examination.Long term neurological and neuropsychological sequelae are reported up to 30–40% in COVID-19 survivors, includingfatigue, myalgia, headache, dysautonomia and cognitive impairment (“brain fog”). A complete understanding of these manifestations is mandatory.