Multicontrast Approaches
Stanislas Rapacchi1
1CNRS Aix-Marseille University, Marseille, France

Synopsis

This presentation presents an overview of multi-contrasts approaches in MRI, from a simple but technical point of view. The presentation starts from two simple examples of multi-contrasts approaches and continues with quantitative multi-contrast approaches. The presentation compares all these approaches in 3 points: 1/ the acquisition schemes that allows to probe multiple contrasts at once, 2/ the underlying model that maps MR signal onto multiple contrasts and allows to disentangle them and 3/ the output contrasts that are eventually provided by the approach of interest. Finally, we will review extensions of multi-contrast approaches with synthetic imaging, segmentation, and standardized reporting.

Summary

This presentation presents an overview of multi-contrasts approaches in MRI, from a simple but technical point of view. The purpose is to provide clinicians with elements of understanding and criticism when using multi-contrast MRI. The presentation starts from some simple examples of multi-contrasts approaches that unlocked contrasts from acquisitions that did not provide those contrasts initially. Then, the core of this talk is to cover the various quantitative multi-contrast approaches, including several steady-state multi-contrast MRI techniques, and the few and recent transient-state multi-contrast approaches. The presentation systematically compares all these approaches in 3 points: 1/ the acquisition scheme that allows to probe multiple contrasts at once, 2/ the underlying model that maps MR signal onto multiple contrasts and allows to disentangle them and 3/ the output contrasts that are eventually provided by the approach of interest. After this overview, we will review extensions of multi-contrast approaches that facilitate clinical integration and add value for the clinicians with synthetic imaging, segmentation, and standardized reporting. Finally, I would like to equip the audience with the scientific metrics of merits that have been proposed to compare the quantitative multi-contrast approaches. These metrics can raise criticism on each of these approaches with tangible and scientific arguments.

Acknowledgements

I would like to acknowledge all sources of material detailled in the references, and my colleagues at the CRMBM for fruitful discussions on building this class.

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