Synopsis

Researchers have developed an array of methods for mapping T₂ and T₂* values in tissue. The choice of the method depends on numerous factors, including the signal model (single versus multi-compartment), scan time, SNR, and the tissue of interest. In all cases, care must be taken to optimize sequence parameters and minimize the impact of confounding features (B₀ and B₁ variations). Moving forward, it is likely that more efficient and robust methods for estimating T₂ and T₂* in tissue will continue to be developed, especially as multi-compartment models continue to illustrate their ability to quantify microstructural features (e.g., myelin content).