Synopsis

This presentation outlines how different tissue properties are reflected by Magnetic Resonance Imaging (MRI) parameters in health and disease. Physical, physiological and pathological origins of multiple MRI contrasts including proton density, longitudinal, transverse and effective transverse relaxation rates, susceptibility and contrast in diffusion-weighted imaging (DWI) are discussed. In addition, it is demonstrated how complementary information on pathological processes are obtained from multiple contrasts.