Sodium is the second most abundant MR active nucleus in the human body and it has a fundamental role in the physiology of human cells. Nevertheless, its low concentration and quick relaxation have limited its application in medicine for a very long time. Research from the last two decades has shown that sodium MRI is no longer a novel MR method. Most of the challenges associated with its application have been addressed. Furthermore, the increasing availability of ultra-high field MR systems (UHF-MRI) in clinical settings has opened new horizons for many medical applications of Sodium MRI.