Synopsis

Serial surveillance of liver iron concentration (LIC) provides guidance for chelation therapy in patients with iron overload. The diagnosis of iron overload traditionally relies on core liver biopsy, which is limited by invasiveness, sampling error, cost and general poor acceptance by patients and their family. Thus noninvasive diagnostic methods such as MRI are highly attractive for quantification of liver iron concentration (LIC). In this talk, we discuss and review the MRI based quantification methods of LIC.