This lecture will provide a clinical and technical perspective on MR perfusion methods and tracer kinetics in musculoskeletal imaging! We will start with the background of different MR perfusion techniques, such as DSC, DCE, ASL and BOLD. Next, a basic understanding of tracer kinetics will be provided and specific challenges in musculoskeletal imaging will be discussed. We move on to MSK applications and end with tips and tricks to get you started.