The current trend of MSK imaging is from qualitative imaging to quantitative imaging, and from imaging that provides anatomy only to imaging that provide compositional, biochemical, metabolic and functional information. In this talk, we will use quantitative MRI in osteoarthritis as an example to discuss this exciting trend. Quantitative MRI standardization and acceleration, as well as automated image analysis will significantly enhance researchers’ ability to apply such techniques to large scale data and will greatly facilitate their clinical translation. Lastly, a few examples on advanced MRI in MSK applications, including UTE/ZTE, DTI, CEST and 7T MRI will be demonstrated.