Kazuya Okamoto1, Takafumi Ohishi2, Sojuro Kato1, Ryuichi Nanaumi3, Kenji Oyama3, and Kazuhiko Fukutani3
1Advanced MRI Development PJ Team, Canon Medical Systems Corp., Kawasaki, Japan, 2Advanced Technology Research Department, Research and Development Center, Canon Medical Systems Corp., Kawasaki, Japan, 3Medical Products Technology Development Center, R&D Headquarters, Canon Inc., Tokyo, Japan
Synopsis
New non-contact cardiac and respiratory gating method have been
developed, which includes an antenna monitoring heart and respiration movement,
and independent triggering pulse generation unit with signal processing
software. The resonance frequency of the dipole antenna was tuned to around
550MHz on the chest. The triggering
pulse generation unit detected and digitized the S11 signals from the antenna.
IIR filter removed the low frequency component and a template matching
technique was used to seek the triggering points at the inflection point of
filtered waveform. As a result, the prospective gating cardiac imaging was
successfully performed for volunteers.
Introduction
Cardiac
and respiratory gating methods with skin contact electrodes and bands are
applied for conventional cardiac and body imaging. But, non-contact cardiac and
respiratory gating methods have been developed recently to improve patient
comfortableness and workflow. The methods using phased array coil profile and
electric characteristics of the tissue are feasible without sequence limitation1,2,
but need complicated hardware. In this work, we have developed an antenna3,4
monitoring heart and respiration movement, an independent triggering pulse
generation unit including signal processing software for seeking the triggering
points, and performed a volunteer study of prospective gating cardiac imaging.Method
Canon 3T system was used with the body and spine array coils to
evaluate this triggering system. The antenna used for the non-contact heart
rate monitor is a meander shape dipole antenna shown in figure 1(a). The
resonance frequency of the dipole antenna in free space is 600MHz, and when the
antenna is placed on the patient chest with a pad (1 cm thickness), the
resonance frequency of the antenna changes to around 550MHz (Figure 1(b)). The
body array coil was set on the antenna for cardiac imaging (Figure 1(c)). The S11
time response data of the antenna at the resonance frequency are monitored via a high-pass filter (112dB) to remove RF pulses. The frequency of the Signal Generator
is adjusted in around 550MHz for each volunteer to find larger deviation of S11
signals due to a cardiac cycle.
Figure 2 shows a triggering pulse
generation unit, which detects the S11 signals and convert it to digital data. A log detector was used to gain dynamic range. The triggering pulses were generated
by triggering pulse generation algorism in the PC, send to the MRI system and
compared to the conventional ECG waveform from ECG electrodes.
An
algorithm to generate triggering pulses at the same timing as the R-wave in
ECG, utilizes the characteristics of S11’s waveforms. In
this study, we concentrated generating cardiac triggering pulse. The low frequency
component derived from abdominal (respiratory) movement was removed by an
infinite impulse response (IIR) filter with a passband from 1 to 15 Hz. Figure
3 shows the waveforms of an ECG (blue), antenna signals before IIR filter (orange)
and IIR filtered antenna signals (green). Since the inflection point of the IIR
filtered waveform almost coincide with the R-wave of the ECG, a template
matching technique was used to seek the triggering points at the inflection
point. The template is created using the waveform for the first 10 seconds or
so and is continuously updated.Results and Discussion
The
algorithm for generating the trigger points from the S11 waveform was evaluated
using the S11 and ECG waveforms obtained by changing the antenna positions and
employing some volunteers outside the magnet. As a
result, the variations of mean value and standard
deviation of
the generated trigger point and the R wave of ECG were 0.3 ms to
20.6 ms and 5.7 ms to 15.5 ms, respectively. As a result, the mean value and dispersion value of the generated
trigger point and the jitter of the R wave of ECG were 0.3 ms to 20.6 ms and
17.3 ms to 46.6 ms, respectively.
The cause of this deviation
depends on the SNR and shape of the S11 waveform, which are affected by the
arrangement of the antenna, the physique of the individual, and the frequency
setting.
In figures 4 and 5, the results of a volunteer study are shown. Figure
4(a) shows the waveforms of the S11 before IIR filter (green), the generated
triggering pulses (orange) and ECG (blue) obtained from a volunteer before the imaging
study. The jitters between the R-waves and the trigger signals were a mean
value and standard deviation of the jitters were -52.6msec and 19.2msec,
respectively. The deviation of the trigger points with respect to the R wave
was large. Multiple inflection points were recognized for some volunteers, and
this time the trigger was generated at the inflection point deviated from the R
wave peak. In the evaluation outside the MRI device, only the inflection point
that coincided with the R wave peak was recognized, stably detected, and a
trigger was generated. In the future, it will be necessary to modify the
algorithm so that the correct trigger point can be searched even when multiple
inflection points are recognized. Figure
4(b) shows these waveforms when retrospective gating cine sequence started.
Even if RF pulse contamination appeared, the triggering pulses were produced at
stable timing and it was favorably obtained prospective gating cardiac images
(Figure 5). We could successfully perform two volunteer’s cine imaging.Conclusion
In
this study, we showed that cardiac gating imaging is possible with a simple
configuration using a high-frequency antenna and a triggering pulse generation
unit. This method is promising to eliminate
attaching electrodes and to enable gating imaging of the heart with a relatively simple configuration.Acknowledgements
No acknowledgement found.References
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