Ananya Goyal1, Garry Gold1, Feliks Kogan1, and Lauren Watkins1
1Stanford University, Stanford, CA, United States
Synopsis
Osteoarthritis (OA)
is a debilitating disease characterized by joint structural degradation. Meniscal
breakdown is linked to OA progression and can
be studied through T2 relaxometry. In this work, we assess the effect of acute
exercise on meniscus T2 relaxation times in individuals with OA. 12 individuals
were scanned before and after performing a single-legged exercise. T2 relaxation
times were computed using a qDESS sequence. We found that acute exercise did not affect the meniscal T2 values in OA subjects; however, significant changes in the maximal
regional T2 change after exercise were observed that may be impacted by knee
loading.
Introduction
Osteoarthritis (OA)
is a highly prevalent and debilitating disease characterized by structural
degradation of the whole joint. The meniscus plays an important role in joint
function, acting to cushion and stabilize the joint. Breakdown of meniscal
function has been linked to pain and can contribute to OA onset and
progression. Meniscal degradation related to OA may
lead to decreased mechanical stiffness and increased permeability compared to
surrounding tissue [1]. T2 and T2* relaxometry has been used to study this
early breakdown of meniscus microstructure [2]. However, not much is known
about the acute effect of exercise and loading on meniscal quantitative MRI
metrics in individuals with OA. In this work, we assess the effect of acute
exercise on meniscus T2 relaxation times in individuals with OA.Methods
Both
knees of twelve individuals with knee OA (aged 61.1 ± 8.8 years, BMI 27.1 ±
5.2) were scanned simultaneously on a 3T MR system (GE Healthcare) using a
bilateral quantitative double-echo in steady-state (qDESS) sequence [3]. All
subjects performed a single-legged (“Exercised”) squat exercise to exhaustion
(70 ± 27 repetitions) while resting their other leg (“Rested”). Scans were
performed both before (“Pre-exercise”) and after (“Post-exercise”) this
exercise (Figure 1A).
T2 relaxation times were computed by fitting the first
and second echoes of qDESS images to an extended-phase graph (EPG) model [3]. In
the Pre-exercise scan, the menisci were automatically segmented using a
deep-learning-based algorithm [4] and manually corrected, as necessary (Figure
1B). Each segmentation was further separated into medial and lateral portions
for analysis. Meniscal portions where more than 50% was missing were excluded (Figure
1C). DESS images and T2 relaxation time maps for the Post-exercise scan were
registered to the Pre-exercise scan using Elastix [5] (Figure 2). The mean T2
relaxation time in the medial and lateral meniscus, as well as across both the
menisci, was calculated.
One-sample t-tests (alpha = 0.05) were performed to assess
if the mean difference in T2 relaxation times associated with the activity
differed from a null hypothesis of zero change. A paired t-test was performed
(alpha = 0.05) to compare changes in T2 relaxation times between exercised and
rested knees, and regionally between the medial and lateral menisci. A One-sample
t-test was also performed to compare the maximum regional T2 change in medial
or lateral menisci to zero, while a paired t-test was performed to compare to the
paired regional T2 change in the rested knee. A paired t-test was chosen due to
its mean-comparing features and greater statistical power.Results
For
the Exercised group, 12 medial and 12 lateral menisci were included in the
study, while for the Rested group, 11 medial and 10 lateral menisci were
included. There was no significant difference in the average meniscal T2
relaxation times for both Pre-exercise and Post-exercise scans, in both the exercised
and rested legs (Figure 3). In the Exercised leg, the average T2 change after
exercise was 0.55 ± 1.2 ms (p=0.14) (Figure 4). Regionally, there were also no
significant changes observed with a mean change of 0.32 ± 1.2 ms (p=0.36) and
0.76 ± 2.1 ms (p=0.25) in the medial and lateral meniscus, respectively.
There
were no statistical differences in the change in T2 relaxation times between
the exercised and rested legs (p=0.29). Similar results were observed when the
meniscus was further segmented into medial (p=0.64) and lateral regions (p=0.38).
When the maximum regional T2 change in the exercised
legs of 11 subjects was assessed, occurring in either the medial (3 subjects) or
lateral meniscus (8 subjects), there was a significant increase in T2 after
exercise (p<0.01). The total average T2 change after exercise was 1.5 ± 1.4
ms (p=0.004) (Figure 5A).
The
maximum regional T2 increase in the exercised leg was also significantly larger
than the paired regional T2 change in the rested leg (p=0.013) (Figure 5B).Discussion
We
observed that T2 did not change significantly in the Exercised leg as a result
of the exercise activity, and there was no significant difference in T2 changes
between legs that were rested and exercised. These results suggest that acute
exercise does not affect the meniscal T2 relaxation times in subjects with OA.
However,
there are significant changes when assessing the maximal regional T2 change in
the medial or lateral menisci of exercised subjects. This may be due to
differences in loading that may have resulted in individual regions of high T2
changes, which were otherwise averaged out on a population basis. The
understanding of these differences in loading between subjects is limited by
the lack of biomechanical information of loading in each subject. Further
studies will also examine a larger population to reduce noise associated with
measuring T2 changes and a heterogeneous population.Conclusion
Acute exercise did not affect the meniscal T2 relaxation times in
subjects with OA; however significant changes in the maximal regional T2 change after
exercise were observed that may be impacted by knee loading. Acknowledgements
Research Support from GE Healthcare
NIH R01-AR077604
NIH R01-EB002524
NIH R01-AR074492
NIH K24-AR062068
NIH R00 EB022634
NIH R21 EB030180
PHIND Seed Grant
Stanford-Philips Research Collaboration
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