Ya-Jun Ma1, Hyungseok Jang1, Zhao Wei1, Mei Wu1, Saeed Jerban1, Eric Y Chang1,2, Jody Corey-Bloom1, Graeme M Bydder1, and Jiang Du1
1UC San Diego, San Diego, CA, United States, 2VA Health system, San Diego, CA, United States
Synopsis
We
combine a Short TR Adiabatic Inversion Recovery preparation and dual-echo
Ultrashort TE data collection with complex Echo Subtraction (ES) (STAIR-dUTE-ES) for both morphological and
quantitative imaging of ultrashort T2
components in the whole brain. The 3D STAIR-dUTE-ES technique provides
robust water suppression within the whole brain and allows accurate ultrashort T2 proton
quantification. UltraShort T2
Proton Fraction (USPF) reduction in multiple
sclerosis (MS) lesions
suggests that the STAIR-dUTE-ES technique has potential for evaluation of
demyelination and remyelination in the diagnosis and treatment of patients with
MS.
Introduction
Direct
imaging of ultrashort T2 components in brain may improve the
specificity of MRI for the assessment and quantification of demyelination (1-6). Most recently, a Short TR Adiabatic
Inversion Recovery prepared UTE (STAIR-UTE) sequence has been used to suppress
water components with different T1s in brain and thus provide selectively
imaging of the ultrashort T2
components contained within it (6). However, accurate imaging and
quantification of ultrashort T2
components are much more challenging in gray matter (GM) than in white
matter (WM) because GM has a much lower myelin proton density. Any residual
water signals may particularly affect the efficacy of ultrashort T2
imaging in GM. In addition, the TR used in STAIR-UTE sequence may not be
sufficiently short to allow the STAIR preparation to completely suppress all
the water signals due to specific absorption rate (SAR) limitations on clinical
MR scanners
(6).
In this study, we combine
the STAIR preparation and dual-echo Ultrashort TE data collection with complex
Echo Subtraction (ES) (STAIR-dUTE-ES)
for both morphological and quantitative imaging of ultrashort T2 components in the whole brain. Dual-echo
acquisition is employed with each spoke of the STAIR-dUTE sequence. The complex
ES algorithm provides much better suppression of residual water components
after the STAIR preparation with STAIR-dUTE-ES
imaging. In vivo healthy volunteer and multiple
sclerosis (MS) patient studies were conducted to assess the feasibility of the STAIR-dUTE-ES technique for robust imaging of ultrashort T2 components in the
whole brain. Quantitative UltraShort
T2 Proton Fraction (USPF) maps were also generated to compare ultrashort
T2s seen in lesions in
MS patients with those seen in Normal White Matter (NWM) in healthy volunteers. Method
Figure 1 shows key features
of the 3D STAIR-dUTE sequence (6). Following an AFP inversion pulse,
a series of UTE k-space spokes (Nsp)
with identical time separation is used for fast data acquisition. After
3D spiral trajectories
using conical view ordering (Figure 1B) dual-echo
acquisition is performed (7). Figure 1C shows the contrast mechanism for ultrashort T2 component imaging
with the STAIR-dUTE sequence.
In this study, complex
subtraction of the second echo (S2) from the first one (S1)
was utilized to further reduce water signal contamination. B0
inhomogeneity map Δ
can be measured before the
complex ES, and be used to calculate the ultrashort T2 signal intensity given by the following equation: Sm
= S1 – S2*exp(-iγΔB0ΔTE) [1]. Magnitude dual-echo subtraction is also be determined for comparison.
USPF is defined as
the ratio of the transverse magnetization of the ultrashort T2 component to the total transverse
magnetization of the brain. The ultrashort
T2 signal is given by Eq. [1] and the total image signal including
both signals from ultrashort T2
components and water can be obtained with a proton density weighted UTE
(PDw-UTE) scan. Moreover, considering the spin evolution difference between the
STAIR-dUTE and UTE sequences, their signal equations should be utilized to
calibrate them and extract the equilibrium state magnetization.
The
3D STAIR-dUTE sequence was implemented on a 3T GE MR750 scanner. Four healthy volunteers and four patients with MS
were recruited for this feasibility study. Informed consent was obtained from all
subjects in accordance with guidelines from the local Institutional Review Board.
The
STAIR-dUTE sequence parameters used for the in
vivo brain study were: 1) the 3D STAIR-dUTE sequence: FOV=22×22×30 cm3,
matrix=140×140×60, TR/TI=140/62 ms, TE=0.032/2.2 ms, Nsp=5, τ=5.7
ms, flip angle=32°, bandwidth=125 kHz, oversampling factor=2.4, scan time=10
min. Results and Discussion
Figure 2 shows a volunteer study with the images
used to generate ultrashort T2 signals employing the methods described above. In
the white matter region, the first echo image shows a high ultrashort
T2 signal. This
signal almost completely disappears on the second echo image, consistent with effective
water suppression and selective imaging of ultrashort T2
component. However, there are still
some residual GM signals on the second echo image and these signals are
negative as evidenced by the π difference between GM and WM on the second echo
phase image. The magnitude of the first echo, magnitude echo subtracted, and
complex echo subtracted images using the STAIR-dUTE sequence are shown in
panels F to H respectively.
Figure 3 shows STAIR-dUTE results from two MS
patients. MP-RAGE and T2-FLAIR images are shown for comparison. Lesions
detected with the two clinical sequences show signal loss on the three groups
of STAIR-dUTE images. Both GM and MS lesions show higher contrast on the
magnitude first echo and the magnitude echo subtracted images as compared with
the complex echo subtracted images.
As can be seen in Figure 4, higher contrast is seen on the USPF
maps compared to the STAIR-dUTE-ES images. The lesions in MS patients showed a lower mean USPF value (5.7±0.7%) compared
with that of NWM (8.9±0.6%) in healthy volunteers, as
is shown in Figure 5. Normal GM (NGM) had a USPF value of 5.9±0.3%.
These results show that STAIR-dUTE-ES measurement of USPF
may be a useful as a biomarker for determining the ultrashort T2
content in MS lesions for diagnosis and monitoring therapy. Conclusion
The
3D STAIR-dUTE-ES technique has potential for evaluation of demyelination and
remyelination in the diagnosis and treatment of patients with MS.Acknowledgements
The authors acknowledge grant support from the NIH (R01NS092650, R01AR075825 and R21AR075851), Veterans Affairs (I01RX002604 and I01CX001388), and GE Healthcare. References
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