Zhaoting Meng1, Gang Feng1, Mingxiang Sun1, Liling Peng1, Min Zhu1, Mu Lin2, and Xin Gao1
1Shanghai Universal Medical Imaging Diagnostic Center, Shanghai, China, 2MR Collaboration, Diagnostic Imaging, Siemens Healthineers Ltd., Shanghai, China
Synopsis
Globally,
nonalcoholic associated fatty liver (NAFLD) is the predominant chronic liver
disease, and it correlates to metabolic syndrome and type 2 diabetes, leading
to cardiac and cerebral arteriosclerosis. In 2020, metabolic associated fatty
liver disease (MAFLD) was newly defined to clarify the pathogenic mechanisms of
this disease and to better guide clinical treatment. We hypothesized that with
MAFLD, previously contradictory imaging results could be better explained.
Liver MRS and FDG PET imaging were conducted simultaneously on an integrated
PET/MR platform, which improved data accuracy. The study also analyzed whether
the liver could be used as a reference tissue for PET imaging.
INTRODUCTION
Previous
studies found that fatty liver disease (FLD) and blood glucose (BG) may affect
fluorodeoxyglucose (FDG) accumulation in the liver, which is often used as a
reference tissue for semi-quantitative assessment, but the data are not
consistent or somewhat controversial1-3. The purpose of this study
was to evaluate hepatic FDG uptake with integrated PET/MR in the scope of
metabolic associated fatty liver disease (MAFLD) which has been newly
re-defined.METHODS
From
July to September 2020, a total of 217 patients (136 males and 81 females) were
evaluated on an integrated PET/MRI scanner (Biograph mMR, Siemens Healthcare,
Erlangen, Germany). Besides whole-body imaging, the liver was scanned using a single-voxel
MR spectroscopy sequence (HISTO, the LiverLab package, Siemens Healthcare,
Erlangen, Germany). Before the examination, the patients were fasting for at
least 6 hours, height, weight, and blood glucose (BG) were routinely measured,
and blood biochemical tests, including triglycerides, HbA1c, and HDL were
performed. Fourteen cases were excluded due to breath-holding failure, and a
total of 203 cases were included in the study.
PDFF
and R2 water was given by HISTO from an ROI of 3 cm2 on
the right liver lobe. Within a similar region, maximum and mean SUVs (corrected
for both body weight [SUV] and lean body mass [SUL]) were measured (Figure 1).RESULTS
Body
mass index (BMI) was
significantly positively correlated with BG, PDFF, and R2 water (r=0.17,
0.42, 0.26, respectively. p=0.016, 0.000, 0.000, respectively). There was also
a significantly positive correlation between BG and PDFF (r=0.2, p=0.004). (Figure
2)
Hepatic
steatosis was diagnosed using PDFF ≥5%4. In
total, 118 of 203 patients were diagnosed as having FLD (58.1%). When grouped
by PDFF (normal[PDFF
< 5%],
mild fatty liver[5%
≤ PDFF < 15%],
moderate to severe fatty liver[PDFF
≥ 15%]), only
the normal and the moderate to severe fatty liver groups showed statistically
significant differences in SUVmax (p=0.024). (Figure 3)
According
to the diagnostic criteria for MAFLD5, 109 patients were diagnosed
as having MAFLD (53.7%). Compared with the non-MAFLD group, SUVmax,
SUVmean, SULmax, and SULmean were all higher
in the MAFLD group, and there were statistically significant differences in SUVmax
and SUVmean
(p=0.005,
0.032,
respectively).
(Figure 4)DISCUSSION
Overweight,
hyperglycemia, fatty liver disease, and other metabolic factors are related to
each other. Hyperglycemia and overweight can lead to liver steatosis, along
with iron deposition, suggesting the underlying process of inflammatory liver
disease6. Compared with FLD, MAFLD suggested that traditional liver
damaging factors such as obesity, metabolic disorders, insulin resistance, and
alcohol abuse have synergistic effects on the liver5. The results
showed that these factors may work together to affect FDG uptake in the liver.
Hepatic SUV is more influenced by MAFLD than by FLD. Previous studies have
found that liver fat deposition decreases FDG clearance rate. One alternative
explanation can be the inflammation caused by hepatic steatosis. Inflammatory
cells such as macrophages are metabolically active and may have a relatively
low glucose-6-phosphatase levels compared with hepatocytes7. In
addition, insulin resistance is one of the causes of FLD8.
Associated hyperglycemia causes FDG redistribution. FDG and glucose compete with
each other for organ clearance, so the FDG blood concentration and tissue
uptake is determined by the blood glucose level.CONCLUSION
MAFLD
is a more meaningful disease concept for clinical diagnosis and treatment
strategies. The use of the liver as a reference tissue in the background of
MAFLD should be done with caution.Acknowledgements
We acknowledge the support for this work from Shanghai Municipal Commission of Economy and Informatization Special Fund for Artificial Intelligence Innovation and Development (2019-RGZN-01079) and Scientific Research Subjects Fund of Shanghai Universal Medical Imaging Technology Limited Company (UV2020Z02).References
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