Lukas Hingerl1, Wolfgang Bogner1, Bernhard Strasser1, Petr Bednarik1, Stanislav Motyka1, Eva Heckova1, Ivica Just1, Alexandra Lipka1, Ovidiu Andronesi2, Stephan Gruber1, Siegfried Trattnig1,3, and Gilbert Hangel1,4
1Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, High Field MR Centre, Vienna, Austria, 2Department of Radiology, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Boston, MA, United States, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4Department of Neurosurgery, Medical University of Vienna, Vienna, Austria
Synopsis
3D-FIDESI-MRSI
combines a free-induction-decay-readout with an echo-readout to permit the
measurement of whole-brain lactate as an important tumor biomarker in
approximately 40 min. This enables the acquisition of signals at
short TE with reduced T2-weighting as well as spectra at long TE
without lipid contamination. Sufficient SNR is ensured by a smaller
and oversampled spherical k-space coverage for the echo-readout using
fast concentric ring trajectories. A test in a healthy volunteer
successfully demonstrates feasible mapping of the major metabolites.
Introduction
FID-MRSI1,2
(free-induction-decay magnetic resonance spectroscopic imaging) is
especially attractive at high field strengths due to the decreased
T2-related signal loss and enables the acquisition of highly resolved
three-dimensional brain metabolic maps in very short times, e.g. a
80x80x47 matrix in less than 16 min with rapid concentric ring
trajectory readout (CRT)3. A big weakness of FID-MRSI is its
inability to quantify the lactate (Lac) resonance at ~1.4ppm4 due
to overlaid lipid signals, which is important for tumor grading.
Thus, we propose to complement FID-MRSI with an additional readout
after spin-echo refocusing (inspired by FIDESI, FID echo
spectroscopic imaging, Kukurova et al.5) at TE=288ms, where
the lipid contamination should be relaxed completely.Methods
A previously
published 3D-FID-MRSI with CRT3 was extended to a sLASER scheme
(Figure 1) by adding a single pair of GOIA6 adiabatic refocusing
pulses (10kHz bandwidth, 10ms duration) to create an echo at TE=288ms. This TE has been shown by Lange et al. to be the optimal
echo-time for Lac quantification4. The final spoilers of the
FID-MRSI readout were moved to the end of the echo-readout. A pair
of gradients were played out between the two adiabatic pulses to null
the 0-th order in-plane magnetization which is built up by the CRT
trajectories to initially move the readout in k-space to the given
circle radii and reach the desired velocity. To maximize the FID
readout length (only 120ms) the placement of the GOIA pulses was
asymmetrical with the second GOIA pulse directly before the spin-echo
readout (also 120 ms). The other sequence parameters were: TR=1690ms; acquisition delay 1.3ms, spectral bandwidth 2778Hz with up to 3
variable temporal interleaves, SAR 100%, FOV 220x220x130mm³, VOI
220x220x80mm³, 1 average, total scan time 39min23sec on a 7T
Siemens Magnetom Scanner with a 32-channel NOVA head coil.
To counteract the
massively reduced signal amplitude and the expected low Lac signal
(in patients) due to the high TE, a reduced k-space fraction was
covered by the echo readout as shown in Figure 2. However both
readouts featured the same number of rings and partitions. The
FID-MRSI matrix size was 64x64x29. The echo-acquisition was
oversampled twice as dense in all three k-space dimensions but with
half the extent, hence cropping was necessary to reduce the FOV. This
resulted in an effective spherical matrix size of 32x32x15 as
measured for the echo readout. iMUSICAL coil
combination7 via a pre-scan image was similarly performed for the
FID and echo scan. The FID-basis set from reference3 was used. An
echo-basis set for LCModel8 fitting of the echo data between 4.2
and 1.0ppm containing only N-acetylaspartate
(NAA), total creatine (tCr), total
choline (tCho) and Lac was simulated for TE=288ms with NMRSCOPEB9.
3D-FIDESI-MRSI with
CRT was tested in vivo in a healthy volunteer as a proof-of-concept.
Healthy subjects don’t show enough Lac for quantification, but we
expect the Lac concentrations up to twice as high as the NAA
concentrationsat TE=288ms4 in tumors.Results
Figure 3 shows
representative spectra of the FID and of the spin-echo acquisition
which visualizes the total relaxation of the lipid signal around 1.4ppm. Metabolic maps maps of the major
three metabolites are displayed in Figure 4 for the FID and the echo
scan as well as glutamate (Glu), glutamine (Gln) and myo-inositol
(mIns) for the FID scan only.Discussion
The proposed
sequence tweaks many critical parameters, such as the ultra-short
acquisition duration of only 120 ms (336 spectral points) at cost of
spectral quality (truncation effects, spectral resolution) or the
very long echo-time (low echo-SNR) in favor of the FID readout,
however still produces promising results by
covering a reduced k-space for reaching an acceptable SNR. The used
adiabatic pulses are insensitive to B1-inhomogeneities, not prone to
chemical shift errors and perform well at 7T, however they require
long TRs due to the increased SAR, therefore limiting fast TR methods
such as CRT-MRSI. For studies where only the Lac signal is of
interest, the GOIA pulses could be exchanged by small bandwidth
non-adiabatic pulses with less SAR requirements to enable shorter
TRs, while setting the transmitter frequency directly on the Lac
resonance. As demonstrated in Figure 3, we observed spectral acoustic
resonance sidebands, most likely originating from the strong crusher
gradient of the second GOIA pulse which is shortly before the readout
and should be removed. The frontal voxels of the echo-scan exhibited
strong baseline distortions without any metabolic signals, possibly
caused by gradient vibrations which resulted in much broader water
sidebands due to B0-inhomogeneities. Problems with truncation
artifacts due to few spectral points could be circumvented by
extrapolating the signal in time domain via prior knowledge or
optimizing the fitting by truncated basis sets. The TR could be reduced even further
(reaching TR~288ms) by using conventional low energy refocusing
pulses, and by acquiring only the ‘left’ side of the echo. This
would result in total measurement times similar than in reference2,
e.g. ~9min for a matrix of 64x64x39 (FID) and respectively 32x32x20
(echo) by accepting some spectral drawbacks10.Conclusion
3D-FID-MRSI can be
enhanced by additional lactate imaging (FIDESI, preliminarily
demonstrated in a healthy volunteer), which is a crucial biomarker
for tumor detection and classification.Acknowledgements
This study was
supported by the Austrian Science Fund (FWF) grants KLI-646, P 30701
and P 34198.References
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