Tuneesh K. Ranota1, Hacene Serrai2, David G. McCormack3, Grace Parraga1,4,5, and Alexei Ouriadov1,2,6
1School of Biomedical Engineering, Faculty of Engineering, The University of Western Ontario, London, ON, Canada, 2Department of Physics and Astronomy, The University of Western Ontario, London, ON, Canada, 3Division of Respirology, Department of Medicine, The University of Western Ontario, London, ON, Canada, 4Robarts Research Institute, London, ON, Canada, 5Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada, 6Lawson Health Research Institute, London, ON, Canada
Synopsis
Hyperpolarized 129Xe gas lung MRI is an efficient technique
used to investigate and assess pulmonary diseases. To improve the performance of 129Xe
MRI in lung imaging a method for high-resolution 3D static ventilation images
using FGRE combined with the key-hole method in a single breath-hold, was
proposed. This technique acquires high-resolution 129Xe 3D static
ventilation isotropic-voxel images from the COVID-19 survivors in a single
breath-hold. The SNR of the images
allowed for the analysis of VDP. This study confirms the feasibility of using
isotropic-voxel acquisition sequence in a single breath-hold MRI to study the
effects of COVID-19 on the lungs.
Purpose
It has been shown that inhaled hyperpolarized gas MRI is a
useful technique in the diagnosis and treatment plan for many pulmonary
diseases. This includes chronic obstructive pulmonary disease (COPD),1 asthma2 and lung cancer.3 However, this technique still suffers from technical
challenges,4 preventing it from finding a niche in clinical application.
Data poor sensitivity restrains the development of several acquisition
techniques,5 namely, isotropic voxel static-ventilation imaging,
accelerated multiple b-value diffusion-weighting MRI,6 and accelerated simultaneous
collection of 129Xe gas and 129Xe within lung
tissue/blood. Nevertheless, by taking
advantage of the recent improvement in xenon polarization, effort has been made
to overcome the low image resolution problem, where isotropic-voxel
high-resolution 3D 129Xe static-ventilation data were collected in a
single 16sec breath-hold from the asthma subjects using FGRE sequence. It was demonstrated that the asthma isotropic-voxel
high-resolution 3D 129Xe static-ventilation images showed sufficient
SNR to generate ventilation-defect- percent7 (VDP) estimates.8 We hypothesize that the isotropic-voxel high-resolution 3D 129Xe
static-ventilation images can be obtained by combining the traditional low-resolution
data acquisition method1 with the keyhole approach.9 In this
proof-of-concept study, we confirm the effectiveness of this idea, by obtaining
both low/high-resolution 3D 129Xe data which were acquired from a
small group of the COVID-19 survivors with sufficient SNR, enough to precisely
calculate the VDP values.Methods
Three COVID-19 survivors with
written informed consent provided to an ethics-board-approved study protocol,
underwent spirometry and 1H/129Xe MRI scanning. 129Xe
imaging was performed at 3.0T (MR750, GEHC, WI) using whole-body gradients
(5G/cm maximum) and a commercial 129Xe quadrature-flex RF coil (MR
Solutions, USA).8 Traditional
resolution xenon static-ventilation images were acquired using a coronal plane
3D FGRE sequence (TE/TR/initial-flip-angle=1.5ms/5.1ms/1.3o, variable-flip-angle,10 Bandwidth=16kHz,
reconstructed matrix size=128x128x16, and FOV=40x40x24cm3, voxel
size=3x3x15mm3) as previously described.7 All images were
acquired in breath-hold (<16 second) after inspiration of 1.0L of gas (129Xe/4He
mixture, 30/70) from functional-residual-capacity. Pre- (baseline) and
post-salbutamol data set acquired for each study subjects. Extra four
traditional low-resolution static-ventilation images were acquired without a
xenon breath-hold to obtain the noise data sets. Isotropic high-resolution-images with 3x3x3 voxel-size
were obtained by sandwiching four noise data sets and one xenon signal data set
(so the total number of slice was 80) and performing 3D Fast Fourier Transform
starting with the z-direction following the key-hole technique steps.9
Hyperpolarized 129Xe gas
(polarization=35%) was obtained from a turn-key, spin-exchange polarizer system
(Polarean 9820 129Xe polarizer).11 1H MRI was performed as previously
described.1
Image
SNR was calculated for five central slices for each coronal view by selecting
two regions of interest with similar size, one inside the lung with homogeneous
signal and one outside the lung containing noise.12 VDP was generated using a semi-automated segmentation
algorithm as previously described.7Results
Figures 1, 2 and 3 show the acquired (traditional) and
reconstructed isotropic-voxel static-ventilation images in coronal view
(Figures 1 and 2, baseline) and axial view (Figure 3, post-salbutamol) for one
COVID-19 survivor. Table 1 summarizes demographic information, as well as
imaging results including SNR and VDP for the isotropic-voxel and traditional
resolution static-ventilation measurements of the COVID-19 survivors. The generated
VDP estimates for the COVID-19 survivors were lower for the isotropic-voxel
data compared the traditional resolution data.
The pre- and post-salbutamol very similar for both cases except Survivors
1, where the post-salbutamol value was more than twice as large. The calculated
mean SNR values of the five isotropic-voxel images of the COVID-19 survivors ranged
between 26 and 29, and between 55 and 70 for isotropic-voxel and traditional
data, respectively.Discussion and Conclusion
In this proof-of-concept study, we demonstrated that 3D
isotropic-voxel 129Xe static-ventilation images can be acquired in a
single 16 second breath-hold using the key-hole technique with sufficient SNR
to analyze VDP. The small number of study
subjects is the main limitation of this work, preventing us from deriving a reliable
conclusion of the VDP estimate accuracy for the high-resolution case. However, the mean values of the high
resolution VDP are comparable to the values reported in the literature obtained
with asthma patients.8
Survivor 1 VDPs show a substantial
difference between the pre and post cases. One possible explanation to this
difference is the unfinished gas-inhalation during the post-salbutamol 129Xe
MRI scan.
Isotropic-voxel
coronal SNR-values were consistent with values reported in the literature.7 The SNR-estimates for the high resolution isotropic-voxel
images was approximately half of the traditional non-isotropic images, but with
voxel-size five times smaller. A rigid and more homogenous
coil13 combined with a
phased-receive-array14 could substantially improve
isotropic-voxel image quality and potentially replace the isotopically-enriched
129Xe with the natural-abundant xenon,15 and consequently, reduce the
cost of 129Xe MRI for patients.
It is known that presently, 129Xe
lung MRI is translating towards a clinical tool, and has recently been approved
and used as such in the UK.16 The North-American xenon
consortium17 expects 129Xe
MRI to be FDA (Food and Drug Administration)
approved any moment from now,
and this opens the door for better diagnoses, treatment planning and treatment
assessment of patients with chronic lung, cardiac and neurodegenerative diseases. This
study establishes the usefulness of 129Xe isotropic-voxel
static-ventilation imaging with a 3D FGRE sequence within a single breath-hold
scan, confirming previous studies conducted on other patients suffering from
lung diseases. Acknowledgements
The
authors would like to thank the research and financial supports received from
Western Research Catalyst Grant and The COVID-19 Rapid Research Fund in
Ontario.
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