Qian Chen1, Jilei Zhang2, and Bing Zhang1
1Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China, 2Philips Healthcare, Shanghai, China
Synopsis
Individuals with subjective cognitive decline (SCD)
were at higher risk of Alzheimer’s disease. Based on community-informed connectome
analysis, we observed decreased intra-module connectivity in superior occipital
gyrus of the visual network and decreased inter-module connectivity in supramarginal
gyrus of the dorsal attention network in SCD subjects. The SCD group also
showed increased intra-module connectivity in the dorsolateral prefrontal
cortex and middle frontal gyrus of the frontoparietal network. The altered
network measures showed significant correlations with cognitive performance on
memory and language. Our findings may benefit a better understanding of the neural
basis underlying early cognitive decline in the SCD stage.
Introduction
Cognitive impairment in Alzheimer’s disease (AD) is a
disconnection syndrome closely associated with functional disconnection of coordinated
neural networks1. Subjective
cognitive decline (SCD), considered to be the preclinical stage of AD, is essential
for the early diagnosis and intervention of symptomatic AD2.
Thus, we aimed to investigate the intrinsic alterations of cortical circuitry in
SCD individuals via resting-state functional magnetic resonance imaging (rs-fMRI)
connectome analysis and to determine its associations with cognitive
performance. Methods
Thirty-six elderly SCD subjects and 32 normal controls
(NCs) underwent neuropsychological tests and rs-fMRI scanning. Based on the
prior template and 10 predefined communities proposed by Gordon3,
we established full connection matrices of 333 cortical parcels and calculated
the within-module degree (WMD) and participation coefficient (PC) of each node4. The WMD is a measure
of connectivity to other parcels within the same community, and the PC is a
measure of the diversity of connectivity across different communities5.
Then we calculated the between-group differences in WMD and PC values and further
analyzed the correlations with cognitive variables in the SCD group. Results
Compared to the NCs, SCD subjects showed increased WMD in the dorsolateral prefrontal cortex (DLPFC,
p < 0.05, FDR corrected) and the middle
frontal gyrus (p < 0.005, uncorrected)
of the right frontoparietal network (FPN). The SCD group was also observed
decreased WMD in the superior occipital gyrus (p < 0.05, FDR corrected) of the left
visual network (VN), and decreased PC in the supramarginal gyrus (p < 0.005, uncorrected) of the left
dorsal attention network (DAN). The WMD value in the DLPFC was positively
correlated with the Auditory Verbal Learning Test (AVLT) short-delayed memory (r
= 0.364, p =0.029), AVLT recognition (r = 0.364, p =0.029),
and Boston Naming Test (BNT; r = 0.356, p = 0.033) performance. Moreover,
the PC value in the supramarginal gyrus was positively correlated with the BNT
score (r = 0.413, p = 0.012). Discussion
Cortical network imbalance characterized by decreased
intra-module connectivity of VN and decreased inter-module connectivity of DAN
in SCD subjects may be a potential indicator for distinguishing individuals at
higher risk of incipient AD dementia from subjects with normal aging. Furthermore,
increased intra-module connectivity of FPN, especially in the right DLPFC, may
serve in a compensatory way for the early cognitive decline. Conclusion
Our results may benefit future researches on the early
diagnosis, preventative intervention, and prognostic evaluation of preclinical AD.Acknowledgements
This
work was supported by the National Natural Science Foundation of China
(81720108022 B.Z., 81971596, X.Z., 82071904, Z.Q.); the Fundamental
Research Funds for the Central Universities, Nanjing University (2020-021414380462);
the key project of Jiangsu Commission of Health (K2019025); Key medical talents
of the Jiangsu province, the "13th Five-Year" health promotion
project of the Jiangsu province (ZDRCA2016064); Jiangsu Provincial Key Medical
Discipline (Laboratory) (ZDXKA2016020); the project of the sixth peak of
talented people (WSN -138). The funders had no role in the study design, data
collection and analysis, decision to publish, or preparation of the manuscript.References
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