Di Tian1, Shuangchun Ma1, Ziqi Xiong1, Xin Li1, Qingwei Song1, Ailian Liu1, and Zhiyong Li1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China, Dalian, China
Synopsis
The
purpose of this study is to explore the correlation between smokers' left atrium (LA) myocardial strain (MS), total ejection fraction (EFtotal) parameters and
smoking parameters. This study
demonstrated that LA global
longitudinal strain (GLS) was significantly impaired and reduced
with prolonged duration of smoking, smoking intensity
and smoking burden.
Main findings
With the increase of smoking
time, smoking intensity and smoking burden, LA GLS were
significantly impaired and decreased.Introduction
According to the World Health
Organization (WHO) data in 2017, as of 2016, the number of tobacco users
worldwide reached 1.3 billion, and more than 6 million people died directly or
indirectly from tobacco smoke damage each year [1]. Many studies
have confirmed the effects of acute or chronic smoking on myocardial
contractile, diastolic properties. At present, related studies have clearly
stated that smoking is not only the most common risk factor for COPD, but also
an independent risk factor for COPD-related pulmonary hypertension (PH).
Smoking is also a risk related to lung cancer, stroke, and cardiovascular
disease [2-4].
In addition, IlgenliTF et al.[5] conducted a
comparative study of 20 healthy young male volunteers who completed the
echocardiographic examination results before and after smoking and found that the
ratio of the peak filling velocity of the tricuspid valve at the end of
diastole to the early diastole of the right ventricle (RV) decreased
significantly at 5 and 15 minutes, proving that smoking impaired the diastolic
function of RV in the acute phase. However, few researchers have used cardiac
magnetic resonance imaging (CMR) to evaluate the effect of chronic smoking on
LA. The purpose of this study is to explore the correlation between smokers' LA
MS, EFtotal parameters and smoking parameters, to provide a
theoretical basis for in-depth understanding of the effects of smoking on the
left atrium.Materials and methods
36 healthy
male volunteers (mean age: 47.22
± 11.49, range: 25-68 years) with different degrees of smoking history
who underwent cardiac 3.0T MRI (HDxt;
General Electric Medical Systems, Waukesha, WI, USA) examinations at the
First Affiliated
Hospital of Dalian Medical University from May 2019 to January 2020 were
included in the study. Scanning parameters included: TR/TE = 3.6/1.6ms, flip
angle = 50°, FOV = 350×350 mm2, matrix size = 192×224, slice
thickness = 10 mm, and slice gap = 0 mm. A questionnaire survey was used to
record and summarize the detailed smoking status of each volunteer. Using fast imaging employing steady state acquisition
(FIESTA) cine sequence imaging, regular scanning levels mainly included the
long axis of the left ventricle, the inflow and outflow tract, the four-chamber
heart, and the short axis of the left ventricle (from the apex to the base)
film images. GLS, global circumferential strain (GCS), global radial strain
(GRS) in LA and other parameters assessed by Medis Suite (Medis Medical Imaging
Systems, Leiden, the Netherlands). The correlation analysis between smoking
parameters and LA MS was completed by SPSS 22.0 (Chicago, IL, USA) software.Result
Smoking
time, smoking intensity and smoking burden was a negatively correlated with LA GLS, respectively (r =-0.383,p =0.021;r =-0.423,p =0.010;r =-0.399,p =0.016). However, there was no a correlation in LA GCS, GRS, LAEF and smoking
parameters (p >0.05).Conclusion
With
the increase of smoking time, smoking intensity and smoking burden, LA GLS are
significantly impaired and decreased.Acknowledgements
no acknowledgementReferences
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