Synopsis

DSC-PWI is dependent on the susceptibility effect caused by paramagnetic gadolinium on T2*-weighted imaging. Dynamic contrast-enhanced (DCE) MR imaging is based on T1 shortening induced by a gadolinium-based contrast bolus passing through tissue. Various quantitative model-based and semiquantitative model-free pharmacokinetic parameters, that reflect microcirculatory structure and function, can be derived using the technique. This lecture will focus on the clinical applications of the contrast-based perfusion-weighted imaging techniques in neuroimaging (e.g. tumor, stroke, seizure).