Overview

MRI is uniquely sensitive to a wide range of tissue contrasts, physical phenomena, and physiological properties. This multivariate sensitivity provides a powerful opportunity for tissue characterization via multiparameter mapping, i.e., quantifying multiple complementary contrast mechanisms, properties, and phenomena in a single imaging session or scan. Multiparametric quantification provies objective, repeatable measurements of multiple biomarkers, which can in turn reveal subtle information about tissue state.

Unfortunately, multiparameter quantification is difficult to perform in moving organs, as it it typically requires precise acquisition timing that conflicts with subject motion. The typical approach is to remove the appearance of motion through electrocardiography triggering and breath-holding, but this is often reliable, uncomfortable, and/or impossible for some patients. New developments in multidimensional imaging have enabled motion-resolved multiparameter mapping—capturing motion instead of removing it—thereby allowing non-ECG, free-breathing multiparameter quantification. This talk will present the foundations and latest developments of these multidimensional approaches, as well as their potential impact on quantitative imaging for neurological, cardiovascular, and oncological applications.

Target Audience

The target audience is any attendee interested in learning about quantitative imaging in the presence of motion, especially multiparameter mapping in the heart, brain, and body.

Objectives

As a result of attending this talk, participants should be able to:

• Understand the challenges that motion presents for multiparameter quantitative MRI
• Understand classical approaches to motion handling that remove the impact of motion on parameter maps
• Understand multidimensional approaches to motion handling that can provide motion-resolved parameter maps

Acknowledgements

No acknowledgement found.

References

No reference found.