Rodent Stroke Models for MRI and monitoring pathological processes
Yuki Mori1
1Center for Translational Neuromedicine, University of Copenhagen, Denmark

Synopsis

Magnetic Resonance Imaging in the live animal is a powerful tool and helps to understand the biological process in the brains from normal to neurodegeneration, including ischemic stroke. The presence of immune/lymphatic activity in the CNS has been recently revealed, and live animal MR imaging plays a crucial role in the monitoring of physiological or pathological processes in the CNS. I will review the pros/cons of rodent stroke models associated with MRI experiments. I will also present the recent results of how the rodent brains react after ischemic insult with several in-vivo MRI approaches, including DWI, DCE, and cellular tracing.

Magnetic Resonance Imaging in the live animal is a powerful tool and helps to understand the biological process in the brains from normal to neurodegeneration, including ischemic stroke. The presence of immune/lymphatic activity in the CNS has been recently revealed, and live animal MR imaging plays a crucial role in the monitoring of physiological or pathological processes in the CNS. I will review the pros/cons of rodent stroke models associated with MRI experiments. I will also present the recent results of how the rodent brains react after ischemic insult with several in-vivo MRI approaches, including DWI, DCE, and cellular tracing.

Acknowledgements

No acknowledgement found.

References

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  2. Fujiwara S, Mori Y, de la Mora DM, Akamatsu Y, Yoshida K, Shibata Y, Masuda T, Ogasawara K, Yoshioka Y. Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats. Sci Rep 2020, 10:8404.
  3. Mori Y, Chen T, Fujisawa T, Kobashi S, Ohno K, Yoshida S, Tago Y, Komai Y, Hata Y, Yoshioka Y. From Cartoon to Real Time MRI: In Vivo Monitoring of Phagocyte Migration in Mouse Brain. Sci Rep 2014, 4:6997.
Proc. Intl. Soc. Mag. Reson. Med. 28 (2020)