Imaging metabolic molecules by MR spectroscopy and fingerprinting
Xin Yu1
1Case Western Reserve University, United States

Synopsis

Magnetic resonance spectroscopic imaging (MRSI), especially hetero-nuclear MRSI, allows in vivo assessment of several fundamental metabolic events without the use of ionizing radiation. In particular, phosphorous-31 (31P) MRSI provides a valuable method to evaluate phosphate metabolites and the phosphorylation processes. This lecture will discuss the development of fast, high resolution 31P MRSI and fingerprinting techniques for quantification of mitochondrial oxidative capacity and metabolic rates in vivo.

Targeted Audience

Basic science and translational researchers who are interested in preclinical and clinical studies on in vivo assessment of tissue metabolism in healthy and diseased conditions.

Objectives

  • Basic understanding of 31P spectroscopy and its applications for assessing tissue metabolism in vivo
  • Current challenges in spectroscopic imaging and potential approaches to address these challenges

Highlights

  • High-energy phosphate metabolism and mitochondrial function in living organisms
  • Traditional spectroscopy and spectroscopic imaging approaches in assessing tissue metabolism
  • Subspace-based spectroscopic imaging approach for high-resolution dynamic metabolic imaging
  • Phosphorous-31 spectroscopy magnetic resonance fingerprinting for quantification of metabolic rate

Acknowledgements

NIH grants R01EB023704, R21EB021013, R21HL126215

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Proc. Intl. Soc. Mag. Reson. Med. 28 (2020)