With the improvement of efficiency and accuracy, multi-parameter quantification has drawn increasingly attention in recent years. Researches has been conducted using multi-parameter quantification in various areas and purposes, including tissues characterization of different anatomical sites, treatment response assessments, multi-center comparison, longitudinal follow-up, radiotherapy applications, imaging biomarkers etc. Most of the researches have shown promising results and indicating the great potential of this technique. In this presentation, we will summarize the development, advantages, clinical applications, challenges and gaps of multi-parameter quantification techniques.