Ting Liu1, Lingxia Zeng1, Xia Wang1, and Jian Yang1
1the First Afliated Hospital of Xi'an Jiaotong University, Xi'an, China
Synopsis
Punctate white matter lesion (PWML) was
the common abnormal findings by MRI in neonates, which might predict poor motor and cognitive outcomes.
Assisted vaginal delivery (AVD) increased brain
injury. But the association between AVD and PWML is not clear. This study
showed the mode of delivery is associated with PWML. AVD markedly
increased the risk of PWML compared with cesarean delivery,
especially vacuum extraction with cesarean section as a
reference. The incidence of II and III-IV grade PWML of neonates with AVD was
much higher than that with cesarean section.
Introduction
White
matter injury
(WMI) was the common abnormal findings by MRI in neonates, especially punctate
white matter lesion (PWML)1,2,which
was ccounted for 20-30%1-3.
The incidence of PWML is
about 20-30%1-3, which might predict
poor motor and cognitive outcomes4-6,16. The process of
delivery may cause brain injury including PWML. Assisted vaginal delivery (AVD) is an important
method to expedite vaginal delivery as soon as possible in emergency
situations. AVD increased the prevalence of cerebral hemorrhage7,8. The
association between AVD and PWML is not clear. Materials and Methods
This was an observational
cohort study included neonatal data from 6 clinical centers from Jan.2014 to Mar.2018 (First Affiliated Hospital of Xi'an Jiaotong
University, Northwest Women and Children's Hospital, Xi'an Children's Hospital,
Xi’an Gaoxin Hospital, Shaanxi Provincial People's Hospital, Ankang City Center
Hospital, Baoji Central Hospital, Affiliated Hospital of Shanxi Medical
University and General Hospital of Ningxia Medical University ). This study has been approved by the institutional review board of the
First Affiliated Hospital of Xi’an Jiaotong University in Xi’an, Shaanxi, China. This study is a part of clinical trial that has been
registered with the Clinical Trials Registry (NCT02637817). Informed
consent was signed by the parents or legal guardian of each baby. Neonates who had undergone magnetic resonance imaging
(MRI) examination and related clinical information were included. MRI was used to diagnose and
classify PWML. Final multivariable
was used to analyze the association of mode of delivery
with PWML. Primary outcome was
the diagnosis of PWML by MRI. Logistic regression was used to evaluate the
association of mode of delivery with PWML adjusted for potentially perinatal
and postnatal confounding variables. Then the grading logistic regression of
head circumference and primipara was carried out.Results
This study collected 4237 neonates and 1806 neonates (762 male) in the
final cohort, 517 (28.6%) were diagnosed with PWML by MRI. The incidence of
PWML in cesarean section, normal vaginal delivery and assisted vaginal delivery
(AVD) group was 24.9%, 30.5% and 46.5%, respectively. Neonates with spontaneous
vaginal delivery marginally increased odds of PWML (odds ratio [OR] 1.34, 95%
CI 1.08-1.68) adjusted for perinatal and
postnatal variables with cesarean section as a reference. AVD group had a higher odd (OR 2.80; 95% CI
1.73-4.52) of PWML. Forceps (OR 1.88, 95% CI 1.04-3.40) and vacuum extraction
(OR 6.25, 95% CI 2.72-14.38) increased the risk of PWML obviously. According to
clinical experience and previous reports, head circumference and primipara have important influence on the choice of delivery
mode. So the further grading analysis of head
circumference and primipara was carried out. The results
showed that no matter normal or AVD, if head circumference >30cm, the larger
the head circumference, the higher the risk of PWML. The incidence of PWML
increased in primipara group with normal vaginal delivery, but it did not occur
in multipara.Discussion
Based on our results it was firstly suggested that the
mode of delivery can affect the risk of PWML. The results showed that vaginal
delivery spontaneously slightly increases the odds of PWML, while AVD can
significantly increase the odds, especially vacuum extraction with cesarean
section as a reference. The incidence of II and III-IV grade PWML of neonates
with AVD was much higher than that with cesarean section. The results of
stratified analysis demonstrated that the larger the neonatal head, the higher
the risk of PWML no matter natural vaginal delivery or AVD. In the population
of multipara, natural vaginal delivery did not increase the risk of PWML, but
AVD still significantly increases the odds ratio of PWML.
The researchers believed that the occurrence of PWML may be related to
the injury of immature oligodendrocytes9, which were very sensitive
to ischemia and hypoxia and prone to injury10. We speculated that
long periods of intermittent uterine contractions during vaginal delivery may
lead a potential hypoxia environment for the fetus, which may increase risk of
PWML. Neonates who experience AVD may have a greater degree of hypoxia. Because
most mothers who need AVD were exhausted or had a prolonged second stage of
labor11, the supply of oxygen to the fetus may be reduced and keep
the fetus in an anoxic environment for longer11,12. It was reported
that neonates with AVD had a lower fetal arterial oxygen saturation levels than
that of neonates with natural vaginal delivery13. Furthermore, neonates with AVD experienced not only the
extrusion of the birth canal, but also the direct extrusion of vacuum
extraction or forcep. This double compression made the fetal head more
vulnerable. It has been confirmed that AVD increased the prevalence of cerebral
hemorrhage compared with natural vaginal delivery14,15.Conclusion
The mode of delivery is associated with PWML. AVD markedly
increased the risk of PWML compared with cesarean
delivery. Acknowledgements
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