Mihika Gangolli1, Wen-Tung Wang1, Neville Gai2, Dzung L. Pham1, and John Butman1,2
1Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States, 2National Institutes of Health, Bethesda, MD, United States
Synopsis
We propose a diffusion acquisition scheme, called “nested
cubes”, consisting of five triplets of three unique mutually orthogonal
directions, providing diffusion weighted data sampled across fifteen noncollinear
directions distributed uniformly across a spherical shell. Data acquired using
this setup facilitates the simultaneous acquisition of dynamic maps of trace
and other diffusion metrics while producing DTI measurements comparable to
those from a standard DTI sequence.
Introduction
Dynamic diffusion imaging provides a promising means of
noninvasively detecting and localizing sources of transient cellular swelling
in the brain. Such swelling is known to occur during and following epileptic
seizures1,2, as well as during cortical spreading
depolarizations3,4.
We propose a diffusion acquisition scheme collecting diffusion weighted images
(DWIs) necessary for diffusion tensor imaging (DTI) that may also be used to
compute time series maps of trace, ADC and eADC with relatively high temporal
and spatial resolution. Our approach can be implemented on a clinical scanner
and has the potential to monitor neurological disorders where transient
cellular edema plays an important role. Methods
The “nested cubes” diffusion scheme was derived by
determining orthogonal triplets that provide optimal coverage of a spherical
shell. The gradient directions can be determined numerically5 but for certain
configurations, a geometric interpretation affords an analytic solution. For 15
non-collinear directions, one can assume that the three directions constituting
an orthogonal triplet are represented by the edges at one vertex of a cube. The
vertices of five differently oriented nested cubes are known to form a regular
dodecahedron6 with vertices uniformly
sampling a sphere. We therefore implemented a gradient table that uses the
orthogonal triplets generated by those five nested cubes.
Diffusion datasets with isotropic spatial resolution
(2x2x2mm3) were acquired in healthy volunteers on Siemens 3T mMR Biograph
(TR/TE = 8800/75 ms) and Philips 3T Achieva (TR/TE = 7400/75 ms) scanners. Three
sets of diffusion weighted orientations (b = 1000 s/mm2) were
collected: five repetitions of three mutually orthogonal directions, 15 unique
orientations (DTI), and 15 orientations consisting of five unique sets of three
mutually orthogonal orientations (nested cubes). A single non-diffusion
weighted volume (b = 0 s/mm2) was collected at the start of each
acquisition. With these parameters, the temporal resolution of the time series
diffusion measures was approximately 30 seconds.
Diffusion datasets were coregistered and processed using
TORTOISE to correct for motion and eddy current distortions as well as to
estimate the diffusion tensor, and fractional anisotropy (FA) maps7. Trace, apparent diffusion
coefficient (ADC) and exponential ADC (eADC) maps were calculated using the
geometric mean of the DWIs collected across 15 directions and the averaged non
diffusion weighted images. Time series maps of trace, ADC and eADC were
calculated from the dynamic scans using each set of three mutually orthogonal
directions. Temporal SNR (tSNR) maps were calculated by dividing the mean of
each dynamic measure by its standard deviation across time. Color FA maps were
calculated by scaling the principal eigenvector (ε1) of the diffusion
tensor by the FA. Results
The total energy between the points formed by the vectors of
the gradient table was calculated using the Electrostatic Energy Minimization
theorem8 to quantitatively compare a standard
15 direction with the nested cubes gradient table (Figure 1). The total energy
between points from a standard 15 direction DTI diffusion vector set was 80.7 distance
units while the total energy between points from the nested cubes vector set
was 83.6 distance units, indicating
that a standard 15 direction DTI gradient table sampled more evenly across a
spherical surface. Temporal SNR (tSNR) of dynamic maps of trace, ADC and eADC calculated from five repetitions of
three mutually orthogonal directions were comparable with the nested cubes
diffusion scheme (Figure 2). Using the repeated orthogonal direction acquisition,
tSNR of trace averaged 24.6 (SD = 16.9), tSNR of ADC averaged 21.2 (SD = 15.1) and tSNR
of eADC averaged 25.9 (SD = 16.8). Using the nested cubes acquisition, tSNR of trace
averaged 24.6 (SD = 15.7), tSNR of ADC averaged 19.9 (SD = 14.1) and tSNR of eADC
averaged 24.6 (SD = 15.8). The root mean square (RMS) errors of trace, ADC and eADC between
the 15 direction DTI and the nested cubes acquisitions were below the range of values in both gray and white matter (Figure 3). Similarly, the RMS error of FA between the two acquisitions was near zero and
below the range of FA in the majority of white matter voxels, with corresponding
regions showing high agreement in DTI based fiber orientation (Figure
4). Discussion
These results demonstrate the feasibility of acquiring
diffusion data that not only allow for the calculation of DTI metrics, but also
provide time series maps of diffusivity measures. A standard 15 direction DTI gradient
table provided even sampling across a spherical surface compared with the
nested cubes gradient table. However, DTI metrics were comparable between the
two sequences. Moreover, acquisition of diffusion data using the nested cubes
diffusion scheme proved advantageous by simultaneously collecting data for
dynamic diffusivity maps with tSNR matching maps calculated using a typical
dynamic diffusion sequence consisting of repeating orthogonal directions.
Implementation of the nested cubes gradient table would therefore efficiently
collect data for DTI and dynamic measurements in a single acquisition, reducing
clinical scan time. Conclusion
The proposed nested cubes acquisition scheme allows
for simultaneous collection of data necessary to compute the diffusion
tensor along with data capable of evaluating the temporal dynamics of ADC and
eADC during evolving cellular edema in neurological conditions including
epilepsy and cortical spreading depolarization in ischemic stroke9, traumatic brain injury10,
and migraine aura11.Acknowledgements
We are grateful to the healthy volunteers who made data
collection for this study possible. Data was collected under protocol
98-CC-0019. This study was supported by the Center for Neuroscience and
Regenerative Medicine. References
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