Sebastian Mueller1, Rüdiger Stirnberg2, Suzan Akbey2, Philipp Ehses2, Klaus Scheffler1,3, Tony Stöcker2,4, and Moritz Zaiss1,5
1High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 3Department of Biomedical Magnetic Resonance, Eberhard Karls University Tuebingen, Tuebingen, Germany, 4Department of Physics and Astronomy, University of Bonn, Bonn, Germany, 5Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany
Synopsis
CEST
MRI provides metabolite-based contrasts but often suffers from poor volume
coverage or spatial resolution. We optimized and included a snapshot 3D-EPI
readout and propose a suitable post-processing pipeline to generate CEST
contrast in the whole brain at clinical B0=3T. It is shown that CEST
MRI with 1.8mm isotropic nominal resolution at a field of view of 256x224x156mm³ is
feasible within 4.3s per presaturation frequency offset. The approach is adaptable
for any presaturation scheme. Exemplarily low power saturation was performed
and fitted Lorentzian amplitudes gave a coefficient of variation <8.5%
across three healthy subjects.
Introduction
CEST MRI
provides contrast of low concentrated metabolites, proteins and is sensitive to
external parameters such as pH value. To generate these contrasts,
magnetization has to be prepared by applying a presaturation module at
different frequency offsets. Since this prepared magnetization state will
decay, CEST MRI requires a fast readout or has to be repeated even within the
same saturation offset for segmented readout. Commonly, CEST MRI is therefore
restricted to a relatively small field of view with few slices or poor spatial
resolution. Therefore, we follow a recent approach at ultra-high field (1) optimizing a whole brain snapshot
3D-EPI readout (2) at a clinical 3T system. This approach
overcomes the issue of limited spatial resolution and volume coverage in CEST
MRI with no additional scan time.Methods
The
3D-EPI based protocol was optimized in five healthy subjects at a clinical 3T
MR scanner (Prismafit, Siemens Healthineers, Erlangen, Germany) with
the vendors 64Rx channel head/neck coil and body coil for transmit. Written
informed consent was obtained from all participants prior to the examination.
In the final protocol the imaging parameters were: nominal matrix size
144x126x88 ([RO=HF]x[PE=AP]x[3D=LR]) at 256x224x156mm³ field of view
(CAIPIRINHA=1x6shift=2 along both PE directions; partial Fourier=6/8
in PE1; BW=1930Hz/pix; TE=11ms; EPI-factor=32; 45 binominal-11 water
excitations per volume; FA=15°; centric reordering with half-elliptical
scanning (2)). This resulted in a readout length of 1.2s for
1201 k-space lines at a nominal isotropic resolution of (1.8mm)³. CEST MRI was
performed at three different B1 values with a total of four interleaved WASABI (3) scans. For presaturation 16x100ms Gaussian
shaped pulses at 50% duty cycle were applied with recovery times of 0s and 12s
for the unsaturated image (M0). Acquisition of each of the 57 frequency offsets
took 4.3s plus one M0 image. This is less than 4:30min for a complete CEST spectrum.
Additionally, T1 was estimated using a saturation recovery EPI sequence. Post-processing
included motion correction using elastix (4), dynamic correction for B0 (5), Z-B1 correction (6) and denoising using principal component
analysis (7). For CEST quantification a 4-pool Lorentzian
model was fitted to the post-processed Z-spectra. With the acquired T1 maps
AREX contrast (8) could be determined.Results
With
the optimized protocol a tSNR of >75 for whole brain coverage with (1.8mm)³
even in the cerebellum was realized. Compared to an established 3D-GRE based
protocol (9,10), at a resolution of (2.34mm)³, the EPI provided
twice the tSNR. Figure 1 shows that B1 correction becomes necessary for whole
brain coverage even at 3T. Z-B1 correction (6) with spline interpolation including three B1
values could correct for this issue. We found homogenous Lorentzian amplitudes
across the whole brain volume with significant gray/white matter contrast for
APT, rNOE and ssMT (Figure 2, Figure 3). Executing the suggested post
processing pipeline, we achieved a coefficient of variation that was below 8.5
% for all fitted amplitudes, both in gray and white matter across three
subjects (examined with final protocol, Table 1). The resulting AREX contrasts
are shown in Figure 4.Discussion
To further
reduce the overall acquisition time of <25min, the interleaved WASABI field
mapping could be replaced by methods like DREAM(11)/3DREAM(12). Reducing time for field mapping to
1min each would save 24% of the entire acquisition duration. Since the 3D-EPI readout
was realized as a snapshot approach, our protocol can be used for any CEST
presaturation module or for example also for CEST MR-fingerprinting (13). With only 4.3s acquisition time per
saturation offset and the high nominal resolution of (1.8mm)³ the approach is currently
one of the best performing CEST MRI protocol at clinical field strength. With
the large field of view and the high spatial resolution both spread out pathologies
and smaller lesions across the whole brain might be investigated with CEST MRI at
the same time.Conclusion
We believe
that the suggested 3D-EPI-based CEST MRI acquisition and post-processing pipeline
will enable a broad variety of applications that could bring CEST MRI further
towards clinical routine.Acknowledgements
The financial support of the Max Planck Society, German Research
Foundation (DFG, grant ZA
814/2-1), and European Union’s Horizon 2020 research and innovation
programme (Grant
Agreement No. 667510) is gratefully acknowledged.References
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