William T Clarke1, Lukas Hingerl2, Wolfgang Bogner2, Christopher T Rodgers3,4, and Ladislav Valkovic4,5
1Wellcome Centre for Integrative Neuroimaging, NDCN, University of Oxford, Oxford, United Kingdom, 2High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 4Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 5Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia
Synopsis
A density-weighted concentric
ring trajectory MRSI sequence is created for 31P-MRSI of the human
brain at 3T. The sequence is assessed in three subjects at five different
acquisition times (7:28 – 1:07 minutes) and compared against resolution and
time-matched 3D cartesian CSI sequences. The proposed CONCEPT MRSI sequences
robustly measure 3D localised PCr/ATP ratios of the human brain 1.5 times
faster than the minimum possible with CSI at a matched repetition time. This
opens the possibility of fast dynamic measurements of PCr/ATP in whole human
cerebrum at 3T.
Introduction
Phosphorous magnetic
resonance spectroscopy (31P-MRS) is able to quantify the brain’s
energy usage through measurements of high-energy phosphate metabolism (1). Dynamic measurements could monitor changing energy
usage during temporally modulating external stimuli such as tDCS (2,3). It is therefore desirable to be able to localise signal to multiple
brain regions simultaneously in a short timeframe.
Typically, 31P-MRS
has been conducted using cartesian 3D-CSI sequences (4). Though 3D-CSI offers optimal SNR for a particular
acquisition time, the minimum acquisition time for a certain resolution and
repetition time is undesirably long (5). Concentric ring MRSI (CONCEPT) has recently been
shown to be an effective pulse-sequence for high-resolution 1H-MRSI
of the brain, permitting fast coverage of k-space per unit scan-time (6,7).
In this work we demonstrate a 31P density-weighted
CONCEPT sequence for fast MRSI of the human motor cortex and cerebrum at 3T (8). The proposed sequence is compared against an
acquisition-weighted cartesian sampled CSI sequence for reduced minimum
acquisition time (9).Methods
A previously published
equidistant ring 3D CONCEPT sequence was modified by introducing Hamming window
density-weighting in all spatial dimensions (10). Density was described in the kxy-plane by
placing rings at given radii and in the kz-direction by changing inter-plane
separation (Fig 1). The number of rings in each plane was reduced to
elliptically sample k-space in the kz-direction. The number of
points in each ring was constant. By varying the number of rings and
z-direction partitions while keeping the maximum k-space coverage identical,
total acquisition time could be modulated. Excitation was achieved using a 2.4
ms shaped constant-phase pulse placed at 250 Hz (i.e., 5.0 ppm) relative to phosphocreatine
(PCr) to ensure a uniform flip angle from phosphoethanolamine (PE) (at ∼6 ppm) to β‐ATP (at ∼−16 ppm).
Three subjects (3M, 25±4 years,
75±14 kg) were scanned using a Siemens 3T Trio (Erlangen, Germany) equipped
with a dual tuned 31P/1H birdcage head coil (Rapid
Biomedical GmbH, Rimpar, Germany). Each subject was scanned using a previously
described CSI sequence (9) with a matrix size 10x10x10 (5&1 averages, 7:38
min & 4:18 min). Then the CONCEPT sequence was repeated five times with a
matched matrix (20, 16, 14, 12 and 10 rings/partitions; 7:25, 4:21, 3:01, 2:00
and 1:07 mins). FoV was 230x230x200 mm3, TR was 1 s, and
the bandwidth was 4000 Hz with 1024 time-samples for the CSI and 2000 Hz with 522
samples for the CONCEPT. After 1H localisation scans and before the 31P
MRSI scans, B0 shimming was conducted placing the shim volume over
the parietal lobe, i.e. targeting the sensorimotor cortex in the first subject
and over the whole cerebrum in subjects two and three.
CSI reconstruction was performed online in ICE, CONCEPT data were
reconstructed offline using the non‐uniform FFT (NUFFT) toolbox with min‐max
Kaiser‐Bessel kernel interpolation and twofold oversampling (11) in MATLAB
(MathWorks, Natick, MA, USA). No density compensation is required. Final
CSI/MRSI data fitting was performed using the OXSA toolbox (12).
Sequences were compared based
on (saturation un-corrected) PCr/ATP ratios and pH measurements calculated from the Pi to PCr
chemical shift. The first subject’s scan data was masked to include only voxels
from the shimmed area, i.e. sensory-motor cortex. The second and third
subjects’ data was masked using FSL Bet (13).Results
In the first subject, the
distribution of PCr/ATP ratios measured in sensorimotor cortex voxels (Fig 2b) by
any duration CONCEPT sequence did not significantly (Wilcoxon Signed Rank test,
p>0.09) diverge from the reference values of the 7:38 minute CSI. In the
shorter sequences (≤3min) the variance increased, and number of voxels excluded
due to CRLB >30% was higher (Fig 2d). Though the distribution of pH
measurements never significantly differed from the reference measurements at
any duration, more than half of the voxels were excluded at ≤3min (Fig 2e).
In the second and third subjects PCr/ATP ratio
and pH maps from 4:21 minute and 3:01 minute CONCEPT appeared qualitatively
comparable, unlike the 4:18 minute CSI, to the 7:38 minute CSI (Fig 3). Comparing
whole brain PCr/ATP and pH distributions to the 7:38-minute CSI reference,
CONCEPT showed no significant difference in PCr/ATP ratios at 7:25, 4:21 &
3:01 min, but only reproduced pH measurement with a matched time measurement (7:25
min).Discussion
Density-weighted CONCEPT MRSI
has been demonstrated for fast (4:21 & 3:01 min) 3D localised 31P-MRS
of the brain at 3T using a single channel volume coil. This demonstrates that
CONCEPT achieves the same quality of data in only 56% of the total scan time of
a CSI sequence with matched voxel size. The performance of a matched time (4:21
min) CONCEPT sequence significantly exceeds that of the shortest possible CSI
scan for a given TR. One-average CSI incurs an SNR penalty due to post-acquisition
reweighting of k-space to reduce point-spread-function ripple.
Either a 3:01 or 4:21-minute
acquisition is short enough to apply repeatedly to monitor changes in energy
metabolism in a dynamic stimulation experiment. Reproducibility of measurements
will be assessed in future work.Conclusion
A CONCEPT MRSI sequence is
able to achieve measurements of the PCr/ATP ratio in the human brain in 3:01
minutes with a nominal voxel size of 10.6 mL at 3T.Acknowledgements
CTR and LV are funded by a Sir Henry Dale
Fellowship from the Wellcome Trust [098436/Z/12/B]. The support of the Slovak Grant Agencies
VEGA [2/0001/17] and APVV [#15–0029] is also gratefully acknowledged. The Wellcome Centre for Integrative Neuroimaging
is supported by core funding from the Wellcome Trust (203139/Z/16/Z).References
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