Nan Wang^{1}, Ailian Liu^{1}, Qingwei Song^{1}, Renwang Pu^{1}, Mingli Gao^{1}, Lihua Chen^{1}, Jiazheng Wang^{2}, Zhiwei Shen^{2}, and Yishi Wang^{2}

^{1}The First Affiliated Hospital of Dalian Medical University, Dalian, China, ^{2}Philips Healthcare, Beijing, China

### Synopsis

The detection and quantification of iron depositon in
cirrhotic liver are important for the diagnosis and treatment. The MR-UTE sequence has advantages in quantifying severe liver iron
overload, and partially solve the problem that severe iron overload cannot be
accurately quantified. mDIXON-Quant sequence could quantify liver R2* value.

### Objective

To
investigate the relationship of R2* value between
ultra-short echo time MRI and mDIXON-Quant sequence.### Methods

27 patients clinically diagnosed with liver cirrhosis
were retrospectively selected for the is study. The data were acquired on a 3.0T
Philips MR from May 2019 to October 2019. Scan sequences included T1-TFE, T2-MVXD-SPIR,
DWI(b=800), mDIXON-Quant, UTE-7ECHO and DYNAMIC (**Table 1**). 12 patients
with liver postoperative patients or intrahepatic occupying disease were excluded.
Data analysis: 15 liver cirrhosis (10 males, 5 females) 9 cases of post hepatitic
cirrhosis, 3 cases of alcoholic cirrhosis, and 3 other causes of liver
cirrhosis. R2* value of the upper right anterior lobe of liver,
right anterior lobe of liver and right posterior lobe of liver were measured by
two observers (with 3 years and 2 years experience, respectively) on an ISP
workstation (**Fig.1**). The mean value of liver data was calculated. Pearson
correlation coefficient was used to test the correlation of R2* value
between UTE and mDIXON-Quant sequence.### Results

ICC values of UTE and
mDIXON-Quant on liver were 0.970 and 0.965, respectively (**Table 2**).
The R2*
value of UTE was 64.88Hz±27.77Hz.
The R2* value of mDIXON-Quant was 50.17Hz±17.51Hz. The
R2* value of UTE was moderately correlated with mDIXON-Quant (P=0.004,
Pearson correlation=0.69, **Fig.2** ).### Conclusion and Discussion

The
MR-UTE sequence has advantages in quantifying severe liver iron overload, and
partially solve the problem that severe iron overload cannot be accurately
quantified[1,2]. mDIXON-Quant sequence could quantify liver
R2* value[3]. The R2* values measured by UTE were moderately
correlated with the R2* of mDIXON-Quant.### Acknowledgements

No acknowledgements found.### References

1. Li
RK, Zeng MS, Qiang JW, et al. Improving Detection of Iron
Deposition in Cirrhotic Liver Using Susceptibility-Weighted Imaging With
Emphasis on Histopathological Correlation. J Comput Assist Tomogr, 2017,
41(1): 18-24.

2. Wu
Q, Fu X, Zhuo Z, et al. The application value of ultra-short echo time MRI in
the quantification of liver iron overload in a rat model. Quant Imaging Med
Surg. 2019, 9(2): 180-187.

3. Zhang
Y, Wang C, Duanmu Y, et al. Comparison of CT and magnetic resonance
mDIXON-Quant sequence in the diagnosis of mild hepatic steatosis[J]. Br J
Radiol. 2018, 91(1091): 20170587.