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Application of intravoxel incoherent motion in preoperative assessment of clinicopathological features of Esophageal Squamous Cell Carcinoma1radiology, Henan Cancer Hospital, Zhengzhou, China
Synopsis
Preoperative assessment of intravoxel incoherent motion in clinicopathologic features of esophageal squamous cell carcinoma. the uploaded file includes objective,method,results,conclusion,references, acknowledgements and figure.
Objective
To explore the value of intravoxel incoherent motion(IVIM) in preoperative evaluation of clinicopathological features of esophageal squamous cell carcinoma (ESCC).Methods
ESCC patients who underwent esophageal cancer resection were prospectively enrolled from April 2016 to June 2017. MRI routine scan and IVIM examination were performed within one week before operation. The quantitative parameters of IVIM, including apparent diffusion coefficient (ADC), diffusion coefficient (D), perfusion coefficient (D*) and perfusion score (f) were measured. The relationship between IVIM parameters and pathological parameters (infiltration depth, lymph node metastasis, differentiation degree, angiolymphatic and perineural invasion) was analyzed.The receiver operating characteristic (ROC) curves were used to evaluate the efficacy of predicting clinicopathological features of ESCC.Results
A total of 31 patients were enrolled in the study .The difference in f value between T1+T2 and T3 was statistically significant (P = 0.03). With the f value of 0.497 as the threshold, the diagnostic efficacy of infiltration depth is highest, and the sensitivity and specificity were 55.6% and 86.4% respectively. The f value of angiolymphatic invasion group was significantly lower than that of noninvasion group, and the differences were statistically significant (P = 0.04). With the f value of 0.408 as the threshold, the diagnostic efficacy of angiolymphatic invasion is highest, and the sensitivity and specificity were 70.6% and 78.6% respectively. ADC value, D value and D* value showed no significant difference among groups.Conclusion
IVIM can be used as a new imaging modality to preoperative evaluate clinicopathological features of ESCC. f values can reflect the infiltration depth and angiolymphatic invasion of ESCC.Acknowledgements
The authors have no acknowledgements to report. No externalfunding source was involved in this investigation.References
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