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Correlation between MR DCE quantitative parameters and E-cadherin expression in gastric cancer1Radiology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
Synopsis
Multiple MR quantitative parameters are associated with E-cadherin expression, and Ktrans 75% is the optimal parameter to evaluate the invasion of gastric cancer. In addition, our study also determine the specific boundary range of Ktrans 75%, Ktrans mean, and Ve mean to predict whether E-cadherin expression has decreased or absented, which provides a new method to early evaluate gastric cancer invasion.
Introduction
To explore the correlation between MR quantitative parameters and E-cadherin expression in gastric cancer, and the feasibility of MR quantitative parameters in predicting the prognosis of gastric cancer.Method
45 patients confirmed as gastric adenocarcinoma by surgical pathology were enrolled in this prospective study. All the subjects underwent dynamic contrast enhance MRI(DCE-MRI) examination on a 3.0T MR scanner(MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany). The DCE raw date were post-processed via Omni-Kinetics software package in GE MITK Work bench(GE Medical, China). The MR quantitative parameters Ktrans, Kep, Ve values in mean, 10%, 25%, 50%, 75%, 90% levels were measured. The specimens of tumors were stained with biomarker E-cadherin, and they were divided into negative and normal expression groups. The Mann-Whitney U test or the independent sample t test was used to compare the differences of each MR quantitative parameter between two groups. In the cases that showed statistically significant between two groups, spearman rank correlation analysis was used to compare the correlation between MR quantitative parameter and E-cadherin expression. The receiver operator characteristic(ROC) curve was used to evaluate the diagnostic efficacy of each quantitative parameter, and Yoden index was used to determine the optimal sensitivity and specificity of each quantitative parameter.Result
Ktrans mean, Ktrans 25%, Ktrans 50%, Ktrans 75%, Ktrans 90%, Ve mean, Ve 50%, Ve 75%, and Ve 90% shows statistically difference between negative and normal expression groups(P<0.05). All corresponding MR quantitative parameters are negatively correlated with E-cadherin expression, and Ktrans 75% is the optimal parameter to evaluate E-cadherin expression(AUC:0.744, Sensitivity:0.882, Specificity:0.679). When Ktrans 75% value is 0.842 to 0.879, Ktrans mean value is 0.641 to 0.668, and Ve mean value is 0.580 to 0.737, the risk of decreased or absent of E-cadherin expression in gastric cancer will increase.Conclusion
Multiple MR quantitative parameters are associated with E-cadherin expression, and Ktrans 75% is the optimal parameter to evaluate the invasion of gastric cancer. In addition, our study also determine the specific boundary range of Ktrans 75%, Ktrans mean, and Ve mean to predict whether E-cadherin expression has decreased or absented, which provides a new method to early evaluate gastric cancer invasion.Acknowledgements
Thanks to the Department of Pathology of the Affiliated Cancer Hospital of Zhengzhou University.References
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Figures
Table 6 Evaluation of the efficacy of E-cadherin expression by MR quantitative parameters
Table 7 Ktrans mean, Ktrans 75%, Ve mean value to evaluate the boundary value of E-cadherin expression in gastric cancer
