Xiangyu Wang1, Fan Lin1, and Yi Lei1
1The First Affiliated Hospital of Shenzhen University, Shenzhen, China
Synopsis
31
male volunteers were examined with VERDICT MRI of the prostate.
The derived VERDICT parameters (the fIC, fEES and fVASC) were analyzed with a histogram based on the whole prostate
volume and the PZ, CG and AS ROIs. There were statistical differences between histogram
parameters and regions of the prostate. Among different anatomical zones, for PZ,
Age has a negative correlation with fIC, and positive correlation with fEES. According to CG, there was also positive correlation
between age and fEES.
purpose
The
aim of this study was to identify differences in the histological features of
the prostate by age- and region-related changes in normal prostatic tissues by
using VERDICT MRI.Materials and Methods
In total, 31 male volunteers were included
in the study. The derived VERDICT parameters (the fIC, fEES and vascular
fraction fVASC) were analyzed with a histogram. Based on the whole prostate
volume and the PZ, CG and AS ROIs, histogram parameters (i.e., the median,
mean, skewness and entropy) were computed. Two-way ANOVA and Pearson
correlation coefficients were performedResults
There were significant
differences between the histogram parameters and regions of the prostate (P
< 0.05). In the PZ, there was a correlation between age and the mean,
median, skewness and entropy of the fIC (r = -0.62 and r= -0.64, r
= 0.53 and r= 0.36, respectively, all P < 0.05). Age was
significant correlated with the statistics of the fEES (r = 0.62, r=
0.63, r= 0.47 and r = -0.49, respectively, all P < 0.001). In
the CG, age was found to have a significant positive correlation with the entropy
of the fIC (r
= 0.60, P < 0.001). There was a significant positive correlation
between age and the mean, median and entropy of the fEES (r = 0.55, r=
0.50 and r= 0.61, respectively, all P < 0.001). Similar to the PZ (r
= 0.53, P < 0.001), age also showed a significant positive correlation
with the entropy of the fVASC (r = 0.61, P < 0.001), but no
correlation with other parameters of the fVASC.Conclusion
VERDICT MRI successfully reveals
microstructural changes
across anatomical zones and age groups in normal prostate glands. Such information
might be helpful for better evaluating prostatic diseases, including benign
prostatic hyperplasia or prostatic cancer in the further.Acknowledgements
This work was supported by the Clinical Research Project of Shenzhen Second Peoples' Hospital. Grant Number: 20193357008.References
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