Antonella Meloni1, Antonio De Luca2, Cinzia Nugara3, Chiara Cappelletto2, Camilla Cavallaro4, Chrysanthos Grigoratos1, Giovanni Donato Aquaro1, Giancarlo Todiere1, Andrea Barison1, Gianfranco Sinagra2, Giuseppina Novo3, Germano Di Sciascio4, and Alessia Pepe1
1MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2University of Trieste, Trieste, Italy, 3University of Palermo, Palermo, Italy, 4Università Campus Bio-Medico, Roma, Italy
Synopsis
We assessed
for the first time the prognostic value of the ΔESPVR (difference
between peak and rest end-systolic pressure-volume relation) index evaluated
during dipyridamole stress-CMR in 196 patients with known or
suspected coronary artery disease. During a mean follow-up time of 53.17±28.21 months 50 cardiac events were recorded. In the
multivariate analysis the independent predictive factors for cardiac events
were diabetes, a ΔESPVR index≤0.02
mmHg/mL/m2, and myocardial fibrosis.
Introduction
The variation between rest and peak stress
end-systolic pressure-volume relation is an afterload-independent index of left
ventricular contractility.1 This index is easily obtained during routine stress
echocardiography1,2 but can be derived also during a stress
cardiovascular magnetic resonance (CMR) exam, that is the gold standard for the
quantification of biventricular volumes.3
The
aim of this study was to assess for the first time the prognostic value of delta rest-stress ESPVR (ΔESPVR) by dipyridamole stress-CMR in patients with known or
suspected coronary artery disease (CAD).Methods
One-hundred and ninety-six consecutive patients (49 females, mean age 62.74±10.66 years) who underwent dipyridamole stress-CMR in a high volume CMR Laboratory
were considered.
Abnormal
wall motion and perfusion at rest and after dipyridamole were analysed.
Macroscopic
myocardial fibrosis was detected by the late gadolinium enhancement (LGE)
technique.
Systolic
blood pressures at rest and stress were recorded in the right arm by using a MR‐compatible
sphygmomanometer. The end-systolic pressure was obtained as LV end-systolic
pressure=0.9*systolic blood pressure. Left ventricular (LV) end-diastolic and
end-systolic volumes (EDV, ESV) were obtained at rest and at peak of stress
from apical vertical long-axis view and horizontal long-axis view using the
biplane Simpson’s method. The ESPVR (mmHg/mL/m2) was obtained as the ratio of
the end-systolic pressure to the LVESVI. The ESPVR was determined at rest and
at peak stress. The ΔESPVR was calculated as the variation between rest and
peak stress ESPVR.1,4Results
An abnormal
stress CMR was found in 52 (26.5%) patients; 36 patients had a reversible
stress perfusion defect in at least one myocardial segment and 16 a reversible
stress perfusion defect plus worsening of stress wall motion in comparison with
rest.
LGE sequences
were acquired in 170 (86.7%) patients and myocardial fibrosis was detected in
90 patients (52.9%).
A ΔESPVR index≤0.02 mmHg/mL/m2 was found in 88 patients
(44.9%).
Mean follow-up time was 53.17±28.21 months (median=49.61 months). Cardiac events were recorded in 50 (25.5%) patients: 5 cardiac deaths, 17 revascularizations
for angina (N=14) or myocardial infarction (N=3), one myocardial infarction, 23 hospitalisations for heart failure
(N=5) or unstable angina (n=18), and 4 ventricular arrhythmias. Table 1 shows
the results of the univariate Cox analysis. Diabetes, family history, LVEF, abnormal stress CMR, myocardial
fibrosis, and reduced ΔESPVR
were significant univariate prognosticators. In the multivariate analysis the independent
predictive factors were diabetes (HR=2.33, 95%CI=1.21-4.51, P=0.012), a ΔESPVR index≤0.02 mmHg/mL/m2 (HR=2.58, 95%CI=1.29-5.13, P=0.007), and myocardial
fibrosis (HR=2.13, 95%CI=1.05-4.31, P=0.036). The Kaplan Meyer curves showing
the impact of each prognostic factor on the development of cardiac events are
shown in Figure 1. The log-rank test revealed a significant difference in all
the curves (diabetes: P=0.016, ΔESPVR
index≤0.02 mmHg/mL/m2: P<0.0001, and myocardial fibrosis: P=<0.0001).Conclusions
ΔESPRV
assessed by CMR provides a prognostic stratification in patients with known or
suspected coronary artery disease, in addition to that supplied by diabetes and
myocardial fibrosis.Acknowledgements
No acknowledgement found.References
1. Bombardini
T, Mulieri LA, Salvadori S, et al. Pressure-volume Relationship in the
Stress-echocardiography Laboratory: Does (Left Ventricular End-diastolic) Size
Matter? Rev Esp Cardiol (Engl Ed) 2017;70(2):96-104.
2. Grosu A, Bombardini
T, Senni M, Duino V, Gori M, Picano E. End-systolic pressure/volume
relationship during dobutamine stress echo: a prognostically useful
non-invasive index of left ventricular contractility. Eur Heart J
2005;26(22):2404-2412.
3. Hundley WG, Bluemke
DA, Finn JP, et al. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on
cardiovascular magnetic resonance: a report of the American College of
Cardiology Foundation Task Force on Expert Consensus Documents. Circulation
2010;121(22):2462-2508.
4. Bombardini T, Zoppe
M, Ciampi Q, et al. Myocardial contractility in the stress echo lab: from
pathophysiological toy to clinical tool. Cardiovasc Ultrasound 2013;11:41.