Merlijn van der Plas1, Sophie Schmid1, Martin Craig2, Michael Chappell2,3, and Matthias van Osch1
1Radiology, C.J. Gorter Center for High Field MRI, Leiden, Netherlands, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Institute of Biomedical Engineering, Research Council UK (EP/P012361/1), University of Oxford, Oxford, United Kingdom
Synopsis
A two-component kinetic model allows for the separation of the macrovascular
and tissue signal. This model relies on the availability of multi-timepoint
data and generates cerebral blood flow, arterial blood volume and arterial transit
time maps. The goal of this study was to validate this separation of the
macrovascular and tissue signal. A 4D-ASL angiography and densely sampled ASL
data were acquired and fitted with different model settings. Fitting the 4D-ASL
angiography with a macrovascular component showed the best fit for the model
with gamma dispersion included but with limited freedom to change the
dispersion parameters.
Introduction
Perfusion images acquired with arterial spin labeling (ASL) are
usually quantified using a single component model to obtain quantitative
cerebral blood flow (CBF) maps, which provide information on the cerebral
hemodynamic status 1,2. However,
when using this single component model, these CBF maps can be contaminated by macrovascular
ASL-signal leading to an overestimation of the CBF 3. Including a macrovascular component into the kinetic model, allows
for isolation and subsequent elimination of this macrovascular effect. This
alleviates the overestimation of the CBF since it separates the ASL signal into
two components, i.e. a macrovascular and tissue component. Such a two-component
kinetic model models vascular signal as a “flow through” compartment and relies
on the availability of multi-time point data. It allows generation of both CBF,
arterial blood volume (aBV), as well as arterial transit time (ATT) maps.
However, only limited validation of this two-compartment model has been
presented. Therefore, the goal of this study was to validate this separation by
using 4D-ASL angiography as gold standard for the macrovascular component and
to study how the separation is affected by the temporal resolution of the
ASL-data. Methods
Four healthy volunteers (23-65y,
3f/1m) were scanned using a 32-channel headcoil on a 3T-scanner (Achieva,
Philips, Netherlands). A 4D-ASL contrast inherent inflow-enhanced angiography
(CINEMA) was acquired as the ground truth for the macrovascular component using
a pCASL labeling scheme and a Look-Locker (LL) 3D-TFE readout 4. Densely sampled
multi-PLD (28 timepoints) pCASL data was acquired by combining time-encoding with
a Hadamard-8 matrix and a LL EPI-readout. Lower temporal resolution data, which
was obtained with and without vascular crushing in the inferior-superior
direction with a velocity encoding cutoff of 4cm/s2, was acquired by
eliminating the LL-readout (7 timepoints, 90° flip-angle) 5, Table 1.
The two-component model within a probabilistic analysis approach in the BASIL
toolkit of the FMRIB’s software library (FSL) was used 3,6,7. For the 4D-angiography data, only
the macrovascular component was fitted for the first five phases. Different
models were fitted to the data, namely with and without the inclusion of a
gamma dispersion kernel. Moreover, the priors of the dispersion kernel
parameters (time to peak and sharpness of the distribution) were altered to
allow more freedom by decreasing the precisions 8. Both the
macrovascular and perfusion components were modeled for the multi-PLD ASL data
which resulted in quantified CBF and aBV maps. The negative free energy (FE),
which combines the accuracy of the model’s fit with a penalty for the number of
free parameters, was calculated and the model’s fit per voxel was analyzed. To
compare the ASL data to the ground truth, the CINEMA data was down sampled to a
conventional ASL spatial resolution before fitting the data. Results
The 4D-ASL angiography was used to compare the different models,
without dispersion, with gamma dispersion and gamma dispersion with more
freedom. Figure 1 shows the model’s fit in four different voxels, overall the
fit with the gamma dispersion kernel included, showed the most similarities
with the ASL signal, which is supported by the lowest mean FE values within the
macrovascular component (Table 2). Figure 2 shows the aBV maps for the different
models for all datasets. The aBV values for the ASL data were much lower than
the aBV values of the (down sampled) CINEMA data. Figure 3 shows the aBV and
CBF maps for the high and low temporal resolution data (with/without vascular
crushing). The temporal resolution of the ASL data set, does affect the
separation of the macrovascular and tissue component, since the aBV values are
higher and the CBF values are lower for the high temporal resolution data. By
employing vascular crushing, almost all of the macrovascular component was
crushed.Discussion and conclusion
Fitting the 4D-ASL angiography with a macrovascular component showed
the best fit and the highest FE values for the model with gamma dispersion
included but with limited freedom to change the dispersion parameters,
therefore it is advised to use this macrovascular model when separating
macrovascular from tissue signal. The temporal resolution of the ASL data does,
however, affect this separation. Moreover, the aBV values differ a lot between the
ASL and the 4D-ASL angiography. Whereas the aBV values of the ASL data are in
line with previous reported values of aBV <5% 3,9,10, literature
values of e.g. the MCA-diameter would support the larger values as observed
from the 4D-ASL angiography data. The
reason for this discrepancy is unknown, but might be related to the fact that
the dynamic pattern of the macrovascular component is too similar to the
perfusion signal for accurate separation or arise due to differences between
EPI and TFE-readout. This last option is supported by the fact that the MIP of
the macrovascular compartment in the EPI-data reflects mainly more distal
arteries, which will exhibit slower blood flow. More research is needed to elucidate
these differences in aBV.Acknowledgements
This work is part of the research programme Innovational Research Incentives Scheme Vici with project number 016.160.351, which is financed by theNetherlands Organisation for Scientific Research (NWO).References
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