Synopsis

Major restructuring occurred in the 2016 classification of brain tumors. All diffuse astrocytic and oligodendroglial tumors are now grouped together and oligodendrogliomas are defined by a 1p/19q-codeletion. The new entity of diffuse midline glioma predominates in children and is characterized by a very poor outcome. Within the group of embryonal tumors, the current classification defined medulloblastoma WNT–activated and medulloblastoma SHH–activated as tumor entities and the new entity of embryonal tumour with multilayered rosettes (ETMR), C19MC-altered was defined. On the other hand, the term primitive neuroectodermal tumor (PNET) was removed from the tumor classification.