This lecture is for radiologists and clinicians, technologists, and scientists interested in musculoskeletal imaging with a special focus on inflammatory rheumatic diseases. The presentation will address how we may improve the diagnostic process in adults and pediatric patients affected by this heterogeneous group of inflammatory arthropathies. It will be discussed not only how the MR protocols can be further optimized considering the constant new technological improvements but also the role of hybrid imaging applying PET/MR. Indeed, PET/MR combining specific tracers and sequences via a whole-body approach may provide simultaneously acquired metabolic, functional and anatomical information characterizing the injured areas at diagnosis and after treatment. Furthermore, the role and application of qualitative and quantitative analyses will be addressed, including the use of machine learning and the assessment of radiomics features in the era of biological therapy.In conclusion, after this presentation, the audience should have a comprehensive overview about promising novel MR and PET/MR applications and the research aspectsthat should be further investigated in inflammatory arthropathies.