Metabolic alterations are a hallmark of cancer, including breast cancer. Magnetic resonance spectroscopy (MRS) and chemical exchange saturation transfer (CEST) can be used in a complementary manner to detect several altered metabolites in breast cancer, including but not limited to several choline metabolites, glucose and glycolytic metabolites, several amino acids, myoinositol, several creatine metabolites, among others. Our recent work has focused on strategies to unequivocally detect endogenous metabolites in breast cancers to assess breast cancer cell aggressiveness and response to chemotherapy. This educational talk will cover the detection and biochemistry of CEST- and MRS-detected cellular metabolites that are altered in breast cancer.

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