Spatiotemporal Encoding MRI imposes phase modulation (quadratic phase modulation-SPEN, hyperbolic phase modulation-xSPEN) on top of the regular encoded signal, opens a new window for enhancing immunity to image distortions and accelerating the acquisition. In this presentation, I will first introduce the principle of spatiotemporal encoding MRI, and then show the state-of-art applications based on SPEN and xSPEN techniques.