Synopsis

This presentation will cover some of the key practical considerations that need to be taken into account when quantifying the relaxometry properties of tissue with a view to maximising precision, robustness, sensitivity and reproducibility. Topics such as acquisition strategy, artefact correction and confounds will be discussed.

Overview

The objective of this presentation is to cover some of the key practical considersations that need to be taken into account when implementing a particular strategy for quantifying the relaxation properties, i.e. T₁ and T₂ and T₂* times, of tissue.

This will include:

• the impact of inhomogeneous magnetic fields (B₀, B₁^- and B₁⁺);
• acquisition scheme, i.e. choosing between 2D and 3D;
• biases introduced by undesired signal pathways when ideal imaging conditions, or model assumptions, are not met;
• collateral MT effects and the impact on quantification;
• the impact of noise on model fitting and parameter precision;
• reproducibility assessment.

Acknowledgements

References